血清非对称二甲基精氨酸在盐敏感高血压患者中的测定及其意义

Determination and significance of serum asymmetric dimethyl arginine in patients with salt-sensitive hypertension

目的探讨血清非对称二甲基精氨酸(ADMA)在盐敏感高血压患者中的测定及其意义。方法选择2011年1月～2012年4月在深圳市福田区中医院住院盐敏感高血压患者60例作为观察组,同期选择血压正常的自愿者60例作为对照组,两组都进行ADMA与血压、血糖、血脂检测。结果观察组患者血中ADMA浓度明显高于对照组(P<0.05)。ADMA与收缩压、舒张压、血糖、低密度脂蛋白胆固醇、总胆固醇呈现正相关(P<0.05)。结论血清ADMA水平升高与盐敏感性高血压的发生发展有着密切关系,ADMA与血压、血糖、血脂等一起参与了盐敏感性高血压的发生,对于判断盐敏感性高血压病情、指导治疗具有一定的临床价值。

Objective To investigate determination and significance of serum asymmetric dimethyl arginine（ADMA） in patients with salt-sensitive hypertension.Methods 60 salt-sensitive hypertension patients in Shenzhen Futian Hospital of TCM from January 2011 to April 2012 were selected as the observation group,and 60 cases of normotensive volun teers at the same period were selected as the control group,both groups were given ADMA and blood pressure,blood sugar and lipid tested.Results The blood ADMA concentrations in the observation group were significantly higher（P ＆lt; 0.05）.ADMA and SBP,DBP,blood glucose,LDL-C,TC had positive correlation（P ＆lt; 0.05）.Conclusion Serum ADMA levels are closely related to the development of salt-sensitive hypertension,the ADMA,blood pressure,blood sug ar,blood lipids and other keys are involved in the occurrence of salt-sensitive hypertension,there are some clinical value for guiding treatment for judging the condition of salt-sensitive hypertension.