克罗米芬方案在体外受精-胚胎移植中的应用

Application of clomiphen protocol on IVF-ET

目的探讨克罗米芬（CC）方案在体外受精-胚胎移植（IVF）应用中,新鲜周期胚胎移植和冷冻周期胚胎移植对临床妊娠的影响.方法回顾性分析1028例克罗米芬微刺激方案胚胎移植周期,包括新鲜周期移植765例,冷冻周期移植263例,比较两组的胚胎种植率和临床妊娠率.结果新鲜周期移植胚胎种植率25.2%,临床妊娠率30.6%;冷冻周期移植胚胎种植率30.6%,临床妊娠率45.6%;两组比较差异均有统计学意义.结论 CC微刺激方案IVF 具有方案简单、费用低、并发症少、病人易接受等特点,尤其采用玻璃化冷冻周期胚胎移植,能显著提高临床妊娠率,值得临床推广和应用.

Objective To investigate the clinical value of transferring fresh embryo and frozen-thowed embryo in clomiphen protocol on IVF. Methods One thounsand and twenty-eight embryo tansfer cycles were analyzed retrospect ively, involving seven hundred sixty-five fresh transfer cycles and two hundred sixty-three frozen-thowed transfer cycles The embryo implantation rate and clinical pregnancy rate were compared between the two groups.Results The embryo implantation rate and clinical pregnancy rate were 25.2% and 30.6% in fresh transfer cycles and were 38.8% and 45.6% in frozen-thowed transfer cycles, there were significantly differences between two groups. Conclusion Minimal stimulation clomiphen protocol is a simple, less cost, fewer complications and easy accepted method. Using this protocol on IVF-FET can significantly improve clinical pregnancy rate ,it may be used widely for clinical treatment.