耐甲氧西林金黄色葡萄球菌感染及其耐药性分析

ANALYSIS OF INFECTION AND DRUG RESISTANCE OF METHICILLIN-RESIST Staphylococcus aureus

目的了解耐甲氧西林金黄色葡萄球菌(MRSA)医院感染临床分布及耐药情况,为临床合理用药提供参考依据。方法采用标本检验和药敏试验方法,对病人标本进行MRSA分离鉴定和药敏试验,并对结果进行分析。结果从病人标本中分离的320株金黄色葡萄球菌中检出MRSA 68株,检出率为21.3%。MRSA菌株主要分离自痰液和咽拭子标本,占61.8%;其次是脓液,占16.2%。MRSA感染患者主要来源科室为ICU和神经外科居多。临床分离的MRSA对苯唑西林、青霉素G耐药率100%;对红霉素、四环素耐药率>50%。结论该医院MRSA感染者主要分布于ICU,以痰标本和咽拭子分离率最高,MRSA普遍耐药。

Objective To know the clinical distribution and the drug resistance of methicillin resistant Staphylococcus aureus（MRSA） infection, to provide the basis for clinics to reasonably select antibiotics. Methods The specimen examination and the drug sensitivity tests were used to detect MRSA infected patient specimens separation and identification and the drug resistance detection. Results Totally 68 strains of MRSA （21.3%） were isolated from 320 strains of Staphylococcus aureus in infected patient specimens. The detection rateof MRSA from sputum and throat swab was the highest （61.8%）. The second is pus, accounted for 16. 2%. The MRSA infected patient were mostly from ICU and Neurosurger- y. Drug resistance of MRSA to oxacillin and penicilli G were 100%. Resistance rates of erythromycin and tetracycline were all above 50%. Conclusion The MRSA infected patient in our hospital were mostly from ICU. The separation rate of MR- SA from sputum and throat swab was the highest. MRSA had widespread drug resistance.