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替罗非班对急性冠脉综合征患者PCI术后炎症因子影响 被引量:8

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摘要 目的 观察替罗非班对急性冠脉综合征患者经皮冠状动脉介入治疗(PCI)术后炎症因子的影响.方法 选取2010年7月至2012年12月在本院接受PCI治疗的183例急性冠脉综合征患者做研究对象,将所有患者根据诊断分为两组:治疗组61例(替罗非班组),术前诊断急性冠脉综合征,经造影确诊后应用替罗非班0.1μg/(kg·min)泵入,持续24~36小时,观察其有效性及安全性;对照组122例,未用替罗非班,采用口服阿司匹林、β受体阻断药、血管紧张素转化酶抑制剂及术中应用肝素.结果 本组研究中对照组PCI前SCD40L 、hs-CRP、MMP-P9水平与PCI后比较;两者比较差异不显著,无统计学意义(P〉0.05).治疗组PCI前SCD40L 、hs-CRP、MMP-P9水平与PCI后比较差异显著,有统计学意义(P〈0.05).结果 表明,治疗组PCI后SCD40L、hs-CRP、MMP-P9水平显著低于PCI前,差异明显有显著性(P〈0.05).结论 急性冠脉综合征患者经替罗非班治疗后可明显降低血清炎症因子的水平,对降低PCI术后造成的心肌损伤有重要作用.
作者 雷达 朱桂平
出处 《中国医刊》 CAS 2013年第6期38-40,共3页 Chinese Journal of Medicine
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同被引文献89

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