摘要
A series of novel N-[（1-aryl-3-phenyl-pyrazol-4-yl）methylene]-2-（halo-o-hydroxyphenyl）hydrazide derivatives was synthesized and the antibacterial activity of each of them was evaluated. The supposed reaction mechanism of acquiring compounds 3a--3d is that catalytic activity is enhanced by the electron-donating groups of the first phenyl ring while decreased by electron-withdrawing groups of that ring. The result of preliminary bioassay shows that the lowest minimal inhibitory concentration（MIC） of the title compounds against Escherichia coli is 2 ℃g/mL. MIC values against Monilia albiean and Staphloeoeeus aureus are as low as 4 ~g/mL. They will be a series of potential antibacterial compounds against fungi and gram-negative bacteria.
A series of novel N-[（1-aryl-3-phenyl-pyrazol-4-yl）methylene]-2-（halo-o-hydroxyphenyl）hydrazide derivatives was synthesized and the antibacterial activity of each of them was evaluated. The supposed reaction mechanism of acquiring compounds 3a--3d is that catalytic activity is enhanced by the electron-donating groups of the first phenyl ring while decreased by electron-withdrawing groups of that ring. The result of preliminary bioassay shows that the lowest minimal inhibitory concentration（MIC） of the title compounds against Escherichia coli is 2 ℃g/mL. MIC values against Monilia albiean and Staphloeoeeus aureus are as low as 4 ~g/mL. They will be a series of potential antibacterial compounds against fungi and gram-negative bacteria.
基金
Supported by the National Natural Science Foundation of China（Nos.20976135, 21176194）.
