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Synthesis and Anti-HIV Activity of Triazolo-fused 3 ',4'-Cyclic and 4'-Spiro Nucleoside Analogues

Synthesis and Anti-HIV Activity of Triazolo-fused 3 ',4'-Cyclic and 4'-Spiro Nucleoside Analogues
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摘要 Triazolo-fused 3',4'-cyclic nucleoside 4'-spiro nucleoside analogues were synthesized by an intramolecular 1,3-dipolar cycloaddition of 4'-azido nucleoside derived azido-alkynes in a regio- and stereo-specific manner. The thy- mine nucleoside base in these target compounds was transformed into the corresponding 5-methyl cytosine component. The synthesized compounds were examined in an MAGI(multinuclear-activation galactosidase indicator) assay for exploring the anti-HIV activity and in a H9 T(human T lymphocytes Hg) assay for measuring the cell toxicity. Triazolo-fused 3',4'-cyclic nucleoside 4'-spiro nucleoside analogues were synthesized by an intramolecular 1,3-dipolar cycloaddition of 4'-azido nucleoside derived azido-alkynes in a regio- and stereo-specific manner. The thy- mine nucleoside base in these target compounds was transformed into the corresponding 5-methyl cytosine component. The synthesized compounds were examined in an MAGI(multinuclear-activation galactosidase indicator) assay for exploring the anti-HIV activity and in a H9 T(human T lymphocytes Hg) assay for measuring the cell toxicity.
出处 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2013年第3期473-476,共4页 高等学校化学研究(英文版)
关键词 4'-Spiro nucleoside 3' 4'-fused nucleoside Biological activity 1 3-Dipolar cycloaddition 4'-Spiro nucleoside 3',4'-fused nucleoside Biological activity 1,3-Dipolar cycloaddition
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