HDGF和VEGF在胃癌组织中的表达及其与肿瘤血管生成的关系

Relationship of HDGF and VEGF Expression with Gastric Cancer Angiogenesis

目的探讨肝癌衍生生长因子(HDGF)、血管内皮生长因子(VEGF)在胃癌组织中的表达与肿瘤组织微血管密度(MVD)之间的关系和临床意义。方法通过免疫组化SP法检测83例胃癌组织、35例正常胃组织中HDGF、VEGF和CD105标记的MVD表达情况,分析它们与胃癌临床病理特征的关系。结果 HDGF、VEGF在胃癌组织中的阳性表达率分别为:66.1%和80.7%,明显高于正常对照组的阳性表达率17.1%和11.4%(P<0.05),胃癌组织中的MVD值为:(33.56±7.59)明显高于常对照组(10.7±3.8)(P<0.05)。HDGF、VEGF的表达强度以及MVD值和肿瘤浸润深度、临床分期、淋巴结转移有明显的相关性(P<0.05)。两者在胃癌组织中的表达存在着正相关(P<0.05)。HDGF、VEGF阳性表达胃癌组织的MVD值明显高于阴性表达的MVD值(P<0.05)。结论 HDGF、VEGF的过表达和微血管生成可能与肿瘤的发生和恶性行为有关,检测该指标对预测胃癌的预后和指导治疗有一定的参考价值。

Objective To investigate the relationship between the expression of hepatoma-derived growth factor （HDGF） and vascular endothelial growth factor （VEGF） and microvessel density of gastric cancer and its significance. Methods The expressions of HDGF, VEGF and MVD in 83 cases of gastric cancer and 35 cases of normal gastric tissue were detected by SP immunohistochemical method, and then their correlations with clinicopathological characteristics were analyzed. Results Positive rates of HDGF （66.1%） and VEGF expressions （80.7%） were significantly higher in gastric cancer tissues than those in the normal gastric tissues （17.1% and 11.4% respectively, P〈0.05） and so did the MVD which was （33.56±7.59） in gastric cancer and （10.7±3.81） in the normal gastric tissues （P〈0.05）. The expression of I-IDGF, VEGF and MVD were closely correlated to the invasive depth, lymph node metastasis and TNM staging of gastric cancer（P〈0.05）. The expressions of HDGF were positively correlated with the expressions ofVEGF （P〈0.05）. The values of MVD in cases with positive expression of HDGF and VEGF were significantly higher than in cases with negative expression of them（P〈0.05）. Conclusion Overexp ression of HDGF and VEGF and angiogenesis might contribute to the tumorigenesis and malignant behaviors of gastric cancer. Detecting the expression of HDGF, VEGF and MVD value probably can predict the prognosis of gastric cancer.