黄芪注射液单次给药对雷替曲塞在大鼠体内药动学研究

Pharmacokinetics behavior of raltitrexed in rats after single injected with Astragali Radix

研究黄芪注射液单次给药后雷替曲塞在大鼠体内药动学行为。将12只SD大鼠,随机分为对照组和联合用药组,对照组大鼠尾静脉注射雷替曲塞,联合用药组大鼠单次尾静脉注射黄芪注射液5 min后,尾静脉注射雷替曲塞,于给药后不同时间采集血样,血样经相关处理后,进行HPLC检测。雷替曲塞与黄芪注射液合用后,其在大鼠体内药动学行为与单独注射雷替曲塞相比,AUC,t1/2β等药动学参数差异较小,经计算无统计学意义。可见单剂量注射黄芪注射液后给予雷替曲塞,雷替曲塞在大鼠体内药动学行为并无显著性改变。

To study pharmacokinetics behavior of Raltitrexed（RTX） after single injected with Radix Astragali（RA）; twelve rats were divided into two groups： RTX（administrated iv. of raltitrexed）; RTX with RA（administrated iv. of raltitrexed after single iv. dose of 3.15 g·kg-1）, rat plasma was collected and processed before HPLC assays; The established HPLC method was rapid, specific and precise. Between RTX and RTX with RA groups, half-life（t1/2）, AUC0-t and CL showed no statistically significant differences; RA co-administration did not affect the pharmacokinetics of raltitrexed.