胰腺肿瘤干细胞研究新进展

Recent progress on pancreatic cancer stem cells

胰腺肿瘤尤其是胰腺导管腺癌的恶性程度高,转移性强,预后差。以往研究表明肿瘤干细胞(cancer stem cells,CSC)在胰腺肿瘤的发生、发展过程中起重要作用,深入了解胰腺肿瘤的发病机制将有助于针对性治疗。在胰腺发育过程中,复杂的信号通路和转录因子决定了其前体细胞分化方向,在胰腺发生恶变过程中,这些因素又参与其中,因而往往可以作为追溯CSC的标志。一些研究也应用特定蛋白来筛选胰腺CSC。现就胰腺CSC的来源、鉴定和靶向治疗进行综述。

Pancreatic neoplasm, especially pancreatic ductal adenocarcinoma tends to be with bad prognosis due to higher grade malignancy and metastasis. Formerly researches suggested that cancer stem cells play an important part in the initiation and process of pancreatic cancer, so that, well understanding on the mechanism of pathogenesis will contribute to a direct treatment on it. Complex signal pathways and transcription factors determined the differentiation of precursor cells during the development of pancreas, whereas, also involved in pancreatic malignant changes, which could be used as markers tracking cancer stem cells. Moreover, several special proteins were also employed as tools for pancreatic cancer stem cells screening. In this text, we reviewed origination and identification of pancreatic cancer stem cells, as well as targeted therapy.