β-榄香烯在抗动脉粥样硬化及再狭窄方面的潜在应用

Potential Applications of β-elemene in Anti-atherosclerosis and Anti-restenosis

β-榄香烯是一种公认的广谱、高效抗肿瘤药物。近年来的研究表明,β-榄香烯具有潜在的抗动脉粥样硬化和抗经皮冠状动脉腔内成形术后再狭窄作用。本文就β-榄香烯在抑制血管生成、抑制血栓形成、改善血液流变学功能、抗氧化损伤、抗炎症反应,以及抑制经皮冠状动脉腔内成形术后再狭窄等几个方面的研究进行综述。

It is well known that β-elemene is a broadly effective antitumor drug. In recent years, many studies suggested that β-elemene also has potential value in the treatment of atherosclerosis and restenosis. In this paper, the effect of β-elemene in inhibition of angiogenesis, inhibition of thrombus formation, improvement of hemorheology, protection against oxidative injuries, anti-inflammation and suppression of restenosis after percutaneous transluminal coronary angioplasty （PTCA） are summarized and reviewed.