特发性炎性肌病骨骼肌功能异常的发生机制
摘要
特发性炎性肌病(idiopathic inflammatory myositis,IIM)是一组以进行性对称性近端肌无力为主要特点,可伴有发热、关节痛、吞咽困难、肺间质病变、心肾受累等表现的临床综合征,临床以多发性肌炎(polymyositis)和皮肌炎(dermatomyosi.tis)最常见。IIM的肌肉病理改变并不全相同,其肌无力的发生、发展和转归机制目前并不十分清楚。多发性肌炎,皮肌炎最常累及的肌肉群依次为髋屈肌、髋伸肌、髋外展肌、颈屈肌、肩外展肌,多发性肌炎肌无力的程度常常重于皮肌炎。
出处
《中华风湿病学杂志》
CAS
CSCD
北大核心
2013年第6期418-420,共3页
Chinese Journal of Rheumatology
基金
国家自然科学基金(81072457)
参考文献28
-
1Harris-Love MO, Shrader JA, Koziol D, et al. Distribution andseverity of weakness among patients with polymyositis, dermato-myositis and juvenile dermatomyositis. Rheumatology (Oxford),2009 , 48: 134-139.
-
2Pryor HJ. Weakness in polymyositis. N Engl J Med, 1973,288:1128.
-
3Hohlfeld R,Engel AG. Coculture with autologous myotubes ofcytotoxic T cells isolated from muscle in inflammatory myop-athies. Ann Neurol, 1991,29: 498-507.
-
4Loell I, Lundberg IE. Can muscle regeneration fail in chronic in-flammation :a weakness in inflammatory myopathies. J InternMed, 2011, 269: 243-257.
-
5Murata K,Daiakas MC. Expression of the costimulatory moleculeBB-l,the ligands CTLA-4 and CD28,and their mRNA in in-flammatory myopathies. Am J Pathol, 1999,155: 453-460.
-
6Murata KY. Sugie K,Takamure M, et al. Expression of thecostimuiatory molecule BB-1 and its receptore in patients withscleroderma-polymyositis overlap syndrome. J Neurol Sci, 2002,205: 65-70.
-
7Xiaoyu D,Yunxia W, Qi F, et al. Expression of B7-homolog 1in polymyositis. Ann Clin Lab Sci, 2011,41: 154-160.
-
8Sabina RL, Sulaiman AR, Wortmann RL. Molecular analysisof acquired myoadenylate deaminase deficiency in polymyositis(idiopathic inflammatory myopathy). Adv Exp Med Biol, 1991,309B: 203-205.
-
9Coley W. Rayavarapu S, Pandey GS, et al. The molecular basisof skeletal muscle weakness in a mouse model of inflammatorymyopathy. Arthritis Rheum, 2012,64: 3750-3759.
-
10Coley W. Rayavarapu S, Pandey GS, et al. The molecular basisof skeletal muscle weakness in a mouse model of inflammatorymyopathy. Arthritis Rheum, 2012,64: 3750-3759.
-
1上原灯纪子,周蕾,巩路.以心肌损害为首发表现的多发性肌炎一例[J].天津医药,2006,34(4):235-235.
-
2谭盛,王羡强.特发性炎性肌病的临床病理分析[J].现代临床医学生物工程学杂志,2006,12(6):468-471.
-
3王国春,卢昕.多发性肌炎和皮肌炎的诊治进展[J].临床内科杂志,2007,24(7):442-446. 被引量:9
-
4袁凯,王国春,卢昕.炎性肌病特异性自身抗体研究进展[J].中华风湿病学杂志,2013,17(4):274-277. 被引量:5
-
5肖亦之,罗卉,周亚欧,刘思佳,左晓霞,李懿莎.五种炎性指标在特发性炎性肌病合并细菌感染中的临床意义[J].中华风湿病学杂志,2017,21(4):258-262. 被引量:4
-
6周佳鑫,唐福林.多发性肌炎和皮肌炎的研究现状[J].中华全科医师杂志,2006,5(8):487-490. 被引量:1
-
7王国春.对特发性炎性肌病诊断标准的新认识[J].中华风湿病学杂志,2008,12(4):219-221. 被引量:7
-
8李纯勇,赵春鹏,李胜宾,张喜秋.股骨干骨折交锁髓内针内固定术后局部出现骨化性肌炎5例[J].中国骨伤,2007,20(7):479-480. 被引量:4
-
9祖宁,王国春.抗Jo-1抗体研究进展[J].中华风湿病学杂志,2009,13(9):641-644. 被引量:4
-
10康增军,王芳.特发性炎性肌病发病机制的研究进展[J].临床合理用药杂志,2012,5(30):145-147.