X连锁凋亡抑制蛋白和生存素在鼻腔鼻窦内翻性乳头状瘤中的表达及意义

Expression and its significance of XIAP and survivin in sinonasal inverted papilloma

目的研究X连锁凋亡抑制蛋白(X-linked inhibitor of apoptosis protein,XIAP)、生存素(Survivin)在鼻腔鼻窦内翻性乳头状瘤(nasal inverted papilloma,NIP)发生、发展及恶变中的表达情况。方法 NIP 45例,正常鼻腔黏膜(nasal cavity mucosae,NM)10例,NIP组按不同病理分级分为三组,即无不典型增生组25例,伴有不典型增生组11例,恶变组9例,通过免疫组化SP法进行XIAP和Survivin检测。结果 XIAP、Survivin在NM、NIP组间的表达具有统计学意义(UXIAP=76.000,PXIAP<0.001;Usurvivin=150.000,Psurvivin=0.036),在NIP不同病理分级中,组织分化程度越低,XIAP与Survivin阳性表达强度越高,无不典型增生组及恶变组间的表达具有统计学意义。XIAP与Survivin表达正相关(rs=0.375,P=0.011)。结论XIAP和Survivin与NIP的发病及恶变有关。

OBJECTIVE To explore the expression of X-linked inhibitor of apoptosis protein （XIAP） and survivin in sinonasal inverted papilloma （NIP） . METHODS Immunohistochemical method was used to detect the expression of XIAP and survivin in 45 specimens of NIP, 10 specimens of nasal cavity mucosa （NM） . There were 25 specimens of NIP without dysplasia, 11 with dysplasia, and 9 with canceration to squamous cell carcinoma （SCC） . RESULTS The positive expression of XIAP and survivin had significantly differences between the NM and NIP group （UxAP=76.000, PxAP 〈 0.001; Usurvivin=150.000, Psorivn=0.036） . The expression between NIP without dysplasia and SCC had significantly differences. The expression of XlAP positively correlated with the expression of survivin （rs=0.375, P=0.011） . CONCLUSION XlAP and survivin were associated with the growth and carcinogenesis of NIP.