锯叶棕提取物治疗BPH伴OAB的疗效观察

Effect study of saw palmetto extract in the treatment of benign prostatic hyperplasia with overactive bladder

目的：探讨锯叶棕提取物治疗BPH伴膀胱过度活动症（OAB）的临床疗效。方法：将2012年7月～2013年3月在我院诊断为BPH伴OAB患者100例随机分为研究组50例及对照组50例，研究组口服锯叶棕提取物（沙芭特）160mg，每天2次；对照组口服坦索罗辛0．2mg，每天1次。两组患者均服药8周，对比观察两组开始服药前、服药8周后的IPSS评分、OABSS评分、生活质量评分、最大尿流率（Qmax）、24h排尿次数、夜尿次数、每次排尿量等指标，观察研究组用药前后的疗效。结果：两组患者OAB较治疗前均有明显好转，治疗前后各项指标差异具有统计学意义（P〈0．05）；除max外，研究组与对照组其余观察指标治疗前后的变化值比较，差异均有统计学意义（P〈0．05）。结论：锯叶棕提取物（沙芭特）对于BPH伴OAB有明显的治疗作用，临床疗效较好。

Objective：To evaluate the clinical efficacy of saw palmetto extract in the treatment of benign prostatic hyperplasia patients with overactive bladder. Methods： 100 case were included and were randomly divided into the trial group （50 cases） and control group（50 cases）. Patients in trial group were adminstrated with saw palmet- to extract at 160 mg and in control group were with tamsulosin at 0.2rag once daily for 8 weeks. The efficacy of treatment were assessed by changes before and after treatment in IPSS, OABSS, Quality of life score, Qmax, ally frequency of micturition, the number of nocturia, voiding volumes. Results： There are significant differences in out- come in trial group between before and after treatment（P〈0.05）. There are no significant difference in the chan- ges before and after treatment betweem two groups. There are significant differences in changes before and after treatment of subjective and objective outcome measures except for Q and voiding volumes（P〈0.05）. Conclusions：Combination saw palmetto extract in treatment of benign prostatic hyperplasia patients with OAB has efficacy.