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长链非编码RNA与前列腺癌的研究进展 被引量：1

Research progress of long non-coding RNAs in human prostate cancer
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摘要 长链非编码RNA(Long non-coding RNA,LncRNA)在人类生命活动过程中发挥着重要的作用,并维持着正常的细胞功能,然而它们的异常表达与肿瘤发生密切相关。近年来,越来越多的研究表明,LncRNA通过类似癌基因或抑癌基因的作用,参与前列腺癌细胞的增殖、侵袭、转移等调控过程,并由于特定LncRNA在肿瘤当中表达的高特异性,可作为前列腺癌诊断及预后的指标。本文对近年来LncRNA与前列腺癌发生、发展的关系及诊治的研究进展作一综述。 Long non-coding RNAs （I.ncRNAs） play a critical role in maintaining normal cell function, while the abnormal expression of them are found related to tumorigenesis. Recently, an increasing number of researches have showed that LncRNAs serve their suppressive and oncogenic function by interacting with proliferation,inva- sion and metastasis of prostate cancer. Because of highly specific expression, some LncRNAs have been used as the marker for diagnosis and prognosis of prostate cancer. This review summarizes the recent progress in research on the relationship between LncRNAs with tumorigenesis and development of prostate cancer.
作者 韩涛 郭宏骞
机构地区 南京大学医学院附属南京鼓楼医院泌尿外科
出处 《临床泌尿外科杂志》 2013年第6期473-476,共4页 Journal of Clinical Urology
关键词 长链非编码RNA 前列腺癌 long non-coding RNA prostatic cancer
分类号 R737.25 [医药卫生—肿瘤]
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参考文献25

  • 1Ponting C P, Oliver P L, Reik W. Evolution and functions of long noncoding RNAs[J]. Cell, 2009, 136: 629--641.
  • 2Caley D P, Pink R C, Trujillano D, et al. Long noncoding RNAs, chromatin, and development[J]. ScientificWorldJournal, 2010, 10 : 90-- 102.
  • 3Mercer T R, Dinger M E, Mattick J S. Long non-coding RNAs: insights into functions[J]. Nat Rev Genet, 2009, 10:155--159.
  • 4Cheung H H, Lee T L, Davis A J, et al. Genome-wide DNA methylation profiling reveals novel epigenetically regulated genes and non coding RNAs in human testicular cancer[J]. Br J Cancer, 2010, 102:419--427.
  • 5Gupta R A, Shah N, Wang K C, et al. Long non-cod ing RNA HOTAIR reprograms chromatin state to promote cancer metastasis[J]. Nature, 2010, 464:1071- 1076.
  • 6Yu W, Gius D, Onyango P. Epigenetic silencing of tumor suppressor gene p15 by its antisense RNA[J]. Nature, 2008, 451:202--206.
  • 7Rossi S, Sevignani C, Nnadi S C, et al. Cancer-associated genomic regions (CAGRs) and noncoding RNAs: bioinformatics and therapeutic implications[J].Mamm Genome, 2008, 19:526--540.
  • 8Kotake Y, Nakagawa T, Kitagawa K, et al. Long non- coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15(INK4B) tumor suppressor gene[J]. Oncogene, 2011, 30:1956-1962.
  • 9Rinn J L, Kertesz M, Wang J K, et al. Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs[J]. Cell, 2007,129:1311--1323.
  • 10Pasmant E, Laurendeau I, Heron D, et al. Characterization of a germ-line deletion, including the entire INK4/ARF locus, in a melanoma neural system tumor family: identification of ANRIL, an antisense noncoding RNA whose expression eoclusters with ARF[J]. Cancer Res, 2007, 67:3963--3969.

二级参考文献9

  • 1Jemal A,Murray T,Ward E,et al.Cancer statistics,2005[J].CA Cancer J Clin,2005,55(1):10-30.
  • 2Bussemakers MJ,van Bokhoven A,Verhaegh GW,et al.DD3:a new prostate-specific gene,highly overexpressed in prostate cancer[J].Cancer Res,1999,59(23):5975-5979.
  • 3Walsh PC.Campbell's urology[M].8th ed.Philadelphia:Elsevier Science,2002.3065-3067.
  • 4Gandini O,Luci L,Stigliano A,et al.Is DD3 a new prostate-specific gene[J]? Anticancer Res,2003,23(1A):305-308.
  • 5de Kok JB,Verhaegh GW,Roelofs RW,et al.DD3PCA3,a very sensitive and specific marker to detect prostate tumors[J].Cancer Res,2002,62(9):2695-2698.
  • 6van Gils MP,Stenman UH,Schalken JA,et al.Innovations in serum and urine markers in prostate cancer current european research in the P-Mark project[J].Eur Urol,2005,48(6):1031-1041.
  • 7Iwakiri J,Granbois K,Wehner N,et al.An analysis of urinary prostate specific antigen before and after radical prostatectomy:evidence for secretion of prostate specific antigen by the periurethral glands[J].J Urol,1993,149(4):783-786.
  • 8Vicentini C,Gravina GL,Angelucci A,et al.Detection of telomerase activity in prostate massage sample improves differentiating prostate cancer from benign prostatic hyperplasia[J].J Cancer Res Clin Oncol,2004,130(4):217-221.
  • 9Fradet Y,Saad F,Aprikian A,et al.uPM3,a new molecular urine test for the detection of prostate cancer[J].Urology,2004,64(2):311-315.

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临床泌尿外科杂志
2013年 第6期

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