一种姜黄素类天然化合物的全合成研究

Study on Total Synthesis of One Curcumin Natural Product

基于姜黄素类天然化合物1-(4′-羟基-3′-甲氧基苯基)-7-(4″-甲氧基)-5-羟基-3-庚酮的多种生物药理活性,对其合成方法进行了探索。以香草醛和和茴香醛为原料,经过Knoevenagel反应、还原、酯化、氧化和缩合等主要反应,合成了目标化合物,并针对各步反应条件进行了优化,反应总收率为12.1%;目标产物及中间体的结构均经过质谱和1 H NMR核磁共振波谱进行了表征。该合成方法具有原料廉价易得、操作简便等优点,具有较高的工业价值。

Based on 1 - （ 3 c methoxy- 4＇ hydroxy） 7 - （4＇- methoxy） - 5- hydroxy- 3 - heptanone with biologically and pharmacologic activity as a natural product, it was prepared from aubepine and vanillin through Knoevenagel reaction, reduction, esterification, oxidation and condensation. Technological parameters of each reaction were optimized, and the total yield was 12.1%. Structures of the title compound and the intermediates were confirmed by MS and 1H NMR. The synthesis method has the advantages of cheap rew materials, simple operation and higher industrial value.