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人乳头瘤病毒16型E5蛋白功能的研究进展 被引量：1

Research progress on human papillomavirus type 16E5 protein
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摘要 人乳头瘤病毒16型(HPV16)E5蛋白具有特殊的生物学活性,在宫颈癌发生过程中起重要作用。HPV16E5蛋白具有转化活性,并可增强E6和E7蛋白的致癌活性。E5蛋白的转化活性主要通过上皮生长因子受体(EGFR)信号上调发挥作用。近年来还发现,HPV16E5蛋白是影响免疫系统和炎症通路的关键因子,可能成为宫颈癌治疗的一个靶标。本文就HPV16E5蛋白当前的研究进展进行综述。 E5 protein of human papillomavirus type 16 plays an important role in cervical carcinogenesis. It has a direct transformation function through up-regulation of epidermal growth factor receptor （EGFR） pathway, and also contributes to the transformation function of E6 protein and E7 protein. In recent years, it has been found that HPV16 E5 protein affects some immunological factors and some key factors in inflam- matory pathway. It is a leading therapeutic target for cervical cancer. Current research progress on HPV16 E5 protein is reviewed in this paper.
作者 史菁菁 张喜凤 谷鸿喜 商庆龙
机构地区 哈尔滨医科大学微生物学教研室
出处 《微生物与感染》 2013年第2期119-123,共5页 Journal of Microbes and Infections
基金 国家自然科学基金(81000726) 黑龙江省留学归国基金(LC2009C26)
关键词 人乳头瘤病毒16型 E5蛋白 致癌 免疫 Human papillomavirus type 16 E5 protein Carcinogenesis Immunity
分类号 R737.33 [医药卫生—肿瘤]
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参考文献34

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同被引文献23

  • 1de Freitas AC, Gomes Leit-io Mda C, Coimbra EC. Prospects of molecu- larly-targeted therapies for cervical cancer treatment [ J ]. Curr Drug Targets,2015,16( 1 ) :77-91.
  • 2de Freitas AC, Coimbra EC, Leit-io Mda C. Molecular targets of HPV on- coproteins: Potential biomarkers for cervical carcinogenesis [ J ]. Bio- chimica et Biophysica Acta ( BBA ) -Reviews on Cancer, 2014, 1845 (2) :91-103.
  • 3Gmiguly N. Human papillomavirus-16 F.5 protein: oncogenic role and therapeutic value [ J 1. Cellular Oncology, 2012, 35 (2) : 67-76.
  • 4Liao S, Deng D, Zeng D, et al. HPV16 E5 peptide vaccine in treat- ment of cervical cancer in vitro and in vivo [ J ]. Journal of Huazhong U- niversity of Science and Technology [ Medical Sciences- , 2013, 33 (6) :735-742.
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  • 6Kim MK, Kim HS, Kim SH, et al. Human papiUomavirus type 16 E5 oncoprotein as a new target for cervical cancer treatment[ J ]. Biochemi- cal Pharmacology, 2010, 80(12) : 1930-1935.
  • 7Li W, Deng XM, Wang CX, et al. Down-regulation of HLA class I an- tigen in human papillomavirus type 16 E7 expressing HaCaT cells: cor- relate with TAP-1 expression[ J]. International Journal of Gynecological Cancer, 2010, 20(2): 227-232.
  • 8Grabowska AK, Kaufmann AM, Riemer AB. Identification of promiscu- ous HPV16-derived T helper cell epitopes for therapeutic HPV vaccine design[J]. Int J Cancer,2015,136( 1 ) :212-224.
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  • 10Campo MS, Graham SV,Cortese MS,et al. HPV-16 E5 down-regulates expression of surface HLA class I and reduces recognition by CD8 T cells [ J ]. Virology, 2010, 407 ( 1 ) : 137-142.

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微生物与感染
2013年 第2期

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