沙丁胺醇在离子液体[BnMIM]PF_6修饰碳糊电极上的电催化氧化及电分析方法

Electrocatalytic Oxidation of Salbutamol at a [BnMIM]PF_6 Modified Carbon Paste Electrode and Its Electrochemical Determination

研究了沙丁胺醇(Salbutamol,SAL)在离子液体1-苄基-3-甲基咪唑六氟磷酸盐([BnMIM]PF6)修饰碳糊电极([BnMIM]PF6/CPE)上的电催化氧化行为和电化学动力学性质。实验结果表明,[BnMIM]PF6/CPE对SAL的电化学氧化具有良好的催化作用。用计时电流法(CA)测定了SAL在[BnMIM]PF6/CPE上的电催化氧化反应速率常数k为(2.10±0.05)×103(mol·L-1)-1·s-1。用微分脉冲伏安法(DPV)测得催化氧化峰电流与SAL的浓度在6.0×10-7～1.0×10-3 mol·L-1范围内呈良好线性关系,检测限(S/N=3)为3.27×10-8 mol·L-1,同时运用该方法对吸入用沙丁胺醇溶液中的SAL含量进行了电化学定量测定。

The electrocatalytic oxidation and electrochemical kinetic of Salbutamol（SAL）were investigated at a 1-Benzyl-3-Methylimidazole hexafluorophosphate（[BnMIM]PF6）modified carbon paste electrode（[BnMIM]PF6/CPE）.The experimental results showed that the[BnMIM]PF6/CPE showed an excellent electrocatalytic activity toward SAL.The reaction rate constant for catalytic oxidation k was obtained as（2.10±0.05）×103（mol.L-1）-1.s-1by chronoamperometry（CA）.The catalytic oxidation peak current of SAL and its concentration had a good linear relationship in the range of 6.0×10-7-1.0× 10-3 mol.L-1,with a detection limit of 3.7×10-8 mol.L-1（S/N=3）obtained by differential pulse voltammetry（DPV）.The proposed method has been successfully applied in the electrochemical quantitative determination of SAL content in the commercial inhaled salbutamol solution.