溶剂浸提条件下鱼腥草中癸酰乙醛的高效提取

Highly Efficient Extraction of Decanoyl Acetaldehyde in Houttuynia cordata thunb under Solvent Immersing

本文采用溶剂浸泡提取鱼腥草挥发油,考察了浸泡溶剂、浸泡温度和浸泡时间等因素的影响,探究了鱼腥草中最关键的抗菌成分之一鱼腥草素(癸酰乙醛)的真实含量。研究发现,室温下采用乙酸乙酯浸泡鱼腥草456h,鱼腥草挥发油的提取率高达0.294%,挥发油中癸酰乙醛的含量高达40.14%,仅检测到少量甲基正壬酮。结果表明,温和的提取条件有效抑制了癸酰乙醛的氧化分解,获得远高于水蒸汽蒸馏条件下的癸酰乙醛含量(0.03%)。该研究为从鱼腥草中高效提取癸酰乙醛提供了一种切实可行的手段。

Houttuynia cordata thumb（HCT）,the so called antibiotic of traditional Chinese medicine,has been widely employed for clinic therapy.However,the effective extraction of houttuynium（decanoyl acetaldehyde）as a main component of HCT remains an intellectual challenge.In this paper,through the solvent immersing method,the essential oil was extracted,and the influence of reaction conditions on the efficiency of decanoyl acetaldehyde extraction were investigated such as the type of solvents,temperature and time.When ethyl acetate was used as solvent and extraction was processed at room temperature for 456h,the maximum extractability of essential oil was 0.294%,and the content of decanoyl acetaldehyde was up to 40.14%in the essential oil,and only trace of 2-undecanone was found.In the procedure,the mild extraction condition has reduced the decomposition of decanoyl acetaldehyde.The current study provides a promise way to highly effective extraction of decanoyl acetaldehyde from HCT on a large scale.