维生素C对神经胶质瘤的影响作用

The Effect of Vitamin C on Glioma

神经胶质瘤是中枢神经系统(CNS)最常见的一类肿瘤,占了颅内原发肿瘤的35%～60%。2007年世界卫生组织(WHO)中枢神经系统肿瘤分类中将胶质瘤分为I～Ⅳ级,其中Ⅲ、Ⅳ级为恶性胶质瘤,大约占所有胶质瘤的77.5%。目前对神经胶质瘤的临床治疗采取以手术治疗为主,结合放疗、化疗等疗法的综合治疗,虽然能延长患者生存时间,但存在高复发率、高致残率、高病死率等问题,总体预后仍然较差。自20世纪70年代以来,维生素C(VC)抗肿瘤作用的研究日益进展,国外的医疗工作者已将其作为肿瘤治疗的补充和替代疗法之一,并报道了静脉注射维生素C治疗神经胶质瘤、卵巢癌、肾细胞癌、乳腺癌、大肠癌、非霍奇金淋巴瘤、前列腺癌、膀胱癌等肿瘤的临床病例,认为其能改善患者的临床症状、提高生存质量、延长生存期。本文就维生素C对神经胶质瘤的治疗作用做一综述。

Glioma is the most common primary tumor of the central nervous system （CNS）, accounting for 35% to 60% of primary intracranial tumors. The 2007 World Health Organization （WHO） classification of tumors of the central nervous system group gliomas into into Ⅰ-Ⅳ grade, among which Ⅲ andⅣ grade malignant glioma accounts for 77.5% of all gliomas, Clinical treatment of glioma includes surgery combined with radiotherapy, chemotherapy and other treatments. Although survival of glioma patients has been prolonged, there is a high relapse rate, high morbidity and mortality. The overall prognosis is still poor. Since the 1970s, the anti-tumor effect of vitamin C （VC） research progress increasingly, foreign medical workers took VC as a complementary and alternative cancer treatment. It has been reported that intravenous vitamin C therapy for glial tumor, ovarian cancer, renal cell carcinoma, breast cancer, colorectal cancer, non-Hodgkin＇s lymphoma, prostate cancer, bladder cancer can improve the patient＇s clinical quality of life and prolong survival. In this article, we did a review on the atiglioma effect of Vitamin C.