先天性肥厚性幽门狭窄相关因素的Logistic回归分析

Logistic Regression Analysis of the Related Factors of Infantile Hypertrophic Pyloric Stenosis

目的探讨与先天性肥厚性幽门狭窄(IHPS)的相关危险因素,为IHPS的预防提供依据。方法采用以医院为基础的病例对照研究,分别对该80例IHPS患儿和80例正常婴儿应用自制一般情况调查表进行分析,筛选出与IHPS发生相关的危险因素。结果 34项指标单因素分析中有7项指标有统计学意义(P均<0.05);其中,6项在多因素Logistic回归分析中有统计学意义(P均<0.05)。分别是CHPS阳性家族史(OR=6.245)、性别(OR=4.652)、孕母吸烟(OR=4.075)、孕期情绪紧张焦虑(OR=3.192)、生后第1周喂养方式(OR=2.817)、母孕初期服用红霉素(OR=2.582)。结论避免IHPS发病的危险因素,对预防IHPS发生具有重要现实意义。

Objective To analyze the main environmentally risky factors of the incidence of infantile hypertrophic py- loric stenosis （IHPS） and provide evidence for the prevention of IHPS. Methods Case - control study and questionnaire were adopted to investigate the risk factors associated with IHPS in 80 [HPS patients and 80 normal infants. Results 7 in- dexes were statistically significant （ P 〈 0. 05 ） among all the 34 indexes of single factor analysis ; 6 indexes were statistically significant （ P 〈 0. 05 ） in the multi - factors logistic regression analysis, including CHPS positive family history （ OR -- 6. 245 ） , gender （OR = 4. 652） , smoking during pregnancy （OR = 4. 075 ） , maternal anxiety （OR = 3. 192） , feeding patterns during the first week （OR = 2. 817 ）, and taking erythromycin in the early pregnancy （OR = 2. 582）. Conclusion Avoiding IHPS risk factors is crucial for the prevention of IHPS.