期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

多功能聚合物作为基因和化疗药物共传递系统的研究进展

Progress of Multifunctional Polymers for Co-delivery of Genes and Therapeutic Agents
下载PDF
导出
摘要 多功能聚合物是目前药物传递系统研究领域的热点。化疗药物和基因共传递给药系统能够提高抗肿瘤协调作用。对多功能聚合物的载药原理和释药特点进行总结,并对其用于基因和化学药物传递的研究进展做简要概述。 Multifunctional polymers for drug delivery have received extensive interest. Co-delivery of chemotherapeutics and gene seems hopeful for achieving synergic anticancer activity. This paper reviewed the current researches about multifunctional polymers as genes and drugs co delivery carriers, Their principles of loading drugs and characterizations of sustained release were also discussed.
作者 王晶 李娟
机构地区 中国药科大学
出处 《亚太传统医药》 2013年第6期75-77,共3页 Asia-Pacific Traditional Medicine
关键词 多功能聚合物 共传递 缓释 肿瘤治疗 Multifunctional Polymers Co-delivery Sustained Release Cancer Therapy
分类号 R730.53 [医药卫生—肿瘤]
  • 相关文献

参考文献11

  • 1MENGYAO ZHENG, YU LIU, OLGA SAMSONOVA, et al. Amphiphilic and biodegradable hy-PEI g-PCL b PEG co- polymers efficiently mediate transgene expression depending on their graft density [J] International Journal of Pharma ceutics, 2012,427(1) :80-87.
  • 2TIAN MENG SUN, JINZHI DU , LIFENG YAN, et al. Self-assembled biodegradable micellar nanoparticles o{ am- phiphilic and cationic block copolymer for siRNA delivery [J]. Biomaterials, 2008,29 (32): 4 348-4 355.
  • 3TIANMENG SUN, JIN ZHI, DU YAN , et al. Simultane- ous delivery of siRNA and paclitaxel via a "Two-in-One" mi celleplex promotes synergistic tumor suppression [J]. ACS Nano,2011,5(2) :1 483-1 494.
  • 4ANNA K. LARSEN, DOMINIKA MALINSKA, IZABELA NOSZELA- PIOTROWSKA ,et al. Polyethylenimine media- ted impairment of mitochondrial membrane potential, respira- tion and membrane integrity: Implications for nucleic acid de- livery andgene therapy[J] Mitochondrion,2012, 12 (1) : 162-168.
  • 5ARCHANA SWAMI, ANlqA AGGARWAL, ATUL PATHAK,et al. Imidanolyl- PEI modified nanoparticles for enhanced gene de- livery[J]. International Journal of Pharmaceutics, 2007 , 335 (1- 2) .- 180-192.
  • 6QI DA HU, HUI FAN, YUAN PING,et al. Cationic supra- molecular nanoparticles for co-delivery of gene and anticancer drug[J]. Chem. Commun, 201l, 47.-5 572-5 574.
  • 7NIKKEN WIRADHARMA , YEN WAH TONG , YI YAN YANG . Self- assembled oligopeptide nanostrnc:mres for co- delivery of drug and gene with synergistic therapeutic effect[J]. Biomaterials, 2009,30 (17):3 100-3 109.
  • 8KIHOON NAM, HYE YEONG NAM, PYUNG HWAN KIM,et al. Paclitaxel conjugated PEG and arginine grafted bioreducible poly (disulfideamine) mieelles for co-delivery of drug and gene[J]. Biomaterials, 2012,33 (32) : 8 122-8 130.
  • 9CHOW KU, SOMMERLAD WD, BOEHRER S, et ah Anti- CD20 antibody (IDEC C2B8, rituximab) enhances efficacy of cytotoxic drugs on neoplastic lymphocytes in vitro: role of cytokines, complement, and caspases [J]. Haematologica , 2002,87(1) :33-43.
  • 10EUNJUNG KIM, YUKYUNG JUNG, HYANGTAE CHOI, et al. Prostate cancer cell death produced by the co-delivery of Bcl- xL shRNA and doxorubicin using an aptamer-eonjugated polyplex [J]. Biomaterials, 2010,31 (16)= 4 592 4 599.
亚太传统医药
2013年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部