生酮饮食对癫痫患儿丙戊酸血浓度的影响

Effect of Ketogenic Diet on Valproic Acid Blood Concentration of Epilepsy Children

目的:观察生酮饮食对癫痫患儿丙戊酸血浓度的影响,以供临床参考。方法:以接受丙戊酸钠治疗的癫痫患儿35例为研究对象,均接受生酮饮食疗法。比较患儿饮食治疗前后丙戊酸血浓度的变化,并观察治疗期间的不良反应。结果:与饮食治疗前比较,治疗后丙戊酸血浓度明显升高,差异有统计学意义(P<0.05)。治疗期间出现不良反应14例,占40.0%,未发生一例因不耐受不良反应而退出者。结论:采用生酮饮食治疗癫痫临床效果满意,可显著提高患儿丙戊酸血浓度。

Objective：Observe the effect of ketogenic diet on valproic acid blood concentration of epilepsy children, for clinical reference. Methods：Choose 35 epilepsy children as the research object, received the ketogenic diet therapy. Compared the changes of valproic acid blood concentration before and after treatment, and observed adverse reactions during treatment. Results： Compared with before treatment, the blood concentration of valproic acid increased after treatment, there was a statistically significant difference （P〈0.05）. During the treatment, 14 cases of adverse reactions, accounted for 40%, there was not a case exit the research because of intolerance to adverse reactions. Conclusion： The clinical curative effect of the ketogenic diet in the treatment of epilepsy children with satisfaction, can significantly increase the serum concentration of valproic acid.