摘要
目的观察舒芬太尼复合氟比洛芬酯用于妇科肿瘤术后持续静脉镇痛的临床效果。方法选择妇科肿瘤全麻术后患者42例,随机分为两组,每组21例,均在术后应用持续静脉镇痛。A组用药:舒芬太尼150μg+托烷司琼6mg,生理盐水稀释至100mL;B组:氟比洛芬酯150mg+舒芬太尼100μg+托烷司琼6mg,生理盐水稀释至100mL。两组持续输注量2mL/h。观察术后6、12、24、48h时两组的疼痛视觉模拟评分(VAS)、Prince-Henry疼痛评分(PHS)、Ramsay镇静评分(RSS)和治疗期间可能出现的毒副反应,镇痛结束后记录患者对镇痛治疗的总体满意度。结果两组术后镇痛治疗期间各时间点疼痛VAS、PHS及RSS比较差异无统计学意义(P>0.05)。两组镇痛结束后对镇痛治疗的总体满意度比较差异无统计学意义(P>0.05)。两组恶心呕吐发生率无显著差异(P>0.05);两组均未出现皮肤搔痒、呼吸抑制、嗜睡及异常出血等不良反应。结论舒芬太尼复合氟比洛芬酯用于妇科肿瘤术后静脉镇痛效果确切,毒副反应轻,是一种安全、有效的镇痛方法。
Objective To investigate the effects of sufentanil combined with flurbiprofen axefil for postoperative analgesia in patients with gynecological tumour. Methods 42 ASA Ⅰ - Ⅱ patients with gynecological tumour after general anesthesia were randomly divided into two groups. Each group had 21 patients. All the patients were applied by continuous intravenous analgesia, continuous infusion rate by 2 ml/h. Group A ： snfentanil 150 μg ＋ tropisetron 6 mg, normal saline diluted to 100 ml. Group B： flarbiprofen axetil 150 mg ＋ sufentanil 100 μg ＋ tropisetron 6 mg, normal saline diluted to 100 ml. Visual analogue scale （VAS） ,Prince-Henry score （PHS）, Ramsay sedation score （RSS） and toxicities were recorded in 6,12,24 and 48 h after surgery. Overall satisfaction rates of these patients were calculated after intravenous analgesia. Results There were no statistical significance in VAS,PHS and RSS between the two groups at all the time points after surgery. There were no sta- tistical significance in overall satisfaction after intravenous analgesia during treatments period. There were also no statistical significance in nausea, vomit, dizzy, somnolence, pruritus, respiratory depression, the rate of abnormal bleeding during treatments period of analgesia. Conclusions PCIA with flurbiprofen axetil 150 mg combined with sufentanil 100 μg injection could be a safe and effective method for postoperative analgesia in patients with gynecological turnout.
出处
《中国肿瘤外科杂志》
CAS
2013年第3期173-175,共3页
Chinese Journal of Surgical Oncology
