鼓室内注射甲泼尼龙治疗突发性聋的临床疗效分析

Transtympanic methylprednisolone for treatment of sudden sensorineural hearing loss

目的评价鼓室内注射甲泼尼龙治疗突发性聋的临床效果。方法选择25例常规方法治疗无效的突发性聋患者,采用鼓膜穿刺,鼓室内注入62.5mg/ml甲泼尼龙0.4～0.5ml,每隔3d1次,3次为1个疗程(治疗组)。选择16例常规方法治疗无效但未行鼓室注射给药的病例作为对照组。结果治疗组总有效率为28.0%(7/25),对照组为6.3%(1/16),两组差异有统计学意义(P<0.05)。鼓室内治疗无效组与有效组的年龄[(35.5±14.8)岁vs.(46.3±6.0)岁]、发病时间[(40.0±26.0)dvs.(16.9±7.4)d]、治疗前气导纯音听力均值[(88.8±31.1)dBvs.(73.9±12.4)dB],差异均有统计学意义(P<0.05)。结论鼓室内注射甲泼尼龙对常规方法治疗无效的突发性聋有一定的疗效。

Objective To evaluate the effect of methylprednisolone intratympanic injection for sudden sensorineural heating loss （SSNHL）. Methods Twenty-five cases were given intratympanic methylprednisolone （62.5 mg/ml） once in three days after failure of conventional therapy, and methylprednisolone administration was performed on 3 separate occasions over the course. Sixteen patients who didn＇t receive methylprednisolone intratympanic injection in the control group went on conventional therapy. Auditory acuity was carried on before therapy and 2 weeks after therapy. Results Hearing improvement was documented in 7 of 25 patients who underwent transtympanic methylprednisolone administration. The effective rate of methylprednisolone therapy group was 28.0%, which was significantly higher than that of control group（6.3%, 1/16）, P 〈 0.05. Conclusion Transtympanic methylprednisolone therapy can improve hearing of patients and may be an alternative treatment for patients with SSNHL for whom conventional therapy had failed.