电化学疗法治疗老年人头颈部癌的疗效

Efficacy of pingyangmycin combined with electroporation therapy on head and neck cancer in the elderly

目的:探讨电化学疗法治疗老年人头颈部癌的疗效。方法:选取30例患有头颈部癌的患者组成试验组,采用电化疗结合肿瘤内注射平阳霉素进行治疗,术后进行放疗,并选取30例采用其他方法治疗的同类患者组成对照组。对所有参试患者进行长期随访。短期疗效评价采用国际通用的四级评定标准,长期随访资料进行生存分析和Logrank检验。结果:随访12个月,28例参试患者均未出现复发。生存分析可见:试验组的平均生存期、中数生存期、3年、5年生存率分别较之对照组明显高出。但两组生存率比较的Logrank检验无统计学意义。结论:电化学疗法是一种安全有效的治疗头颈部癌的方法之一。

Objectives To investigate the effects of pingyangmycin combined with electroporation therapy on head and neck cancer in the elderly. Methods 30 patients with head and neck cancer （test group） were treated with electroporation therapy combined with pingyangmycin intratumorally injection, and then received postoperative radiotherapy. Another 30 patients with head and neck cancer （control group） were treated with other treatments. All participating patients received a long-term follow-up. The short-term effects were assessed by the international general four assessment standardS, and the long-term follow-up data were analyzed by survival analysis and Logrank inspection. Results No local recurrence was recorded in 28 patients during the follow-up of 12 months. The average survival period, the median survival period, 3- and 5-year survival rates of the test group were significantly higher than those of control group. But the survival rates between the two groups were not significantly different by Logrank test. Conclusion Electrochemical therapy was one of the safe and effective methods for head and neck cancer.