抗结核治疗后血清α_1-MG、β_2-MG、Hs-CRP与UA水平的关系

Association of serum α_1-MG, β_2-MG, and Hs-CRP with UA level after antituberculosis treatment

目的:探讨肺结核(PTB)患者抗结核治疗后血清中α1微球蛋白(α1-MG)、β2微球蛋白(β2-MG)、超敏C反应蛋白(Hs-CRP)与血尿酸(UA)水平关系及其联合检测对评价抗结核药物早期肾损害的临床价值。方法:在抗结核治疗前及治疗结束时分别抽取空腹静脉血3.0mL,进行相关血清学测试。结果:抗结核治疗后PTB患者血清中UA、α1-MG、β2-MG、Hs-CRP浓度显著高于治疗前,差异有统计学意义(P<0.05,P<0.01,P<0.01,P<0.01),单项阳性率较高,联合检测时阳性率高达87.5%,差异有统计学意义(P<0.05)。血清UA浓度升高与α1-MG、β2-MG、Hs-CRP呈显著正相关(r=0.64、0.72、0.73,P<0.01)。结论:PTB患者抗结核治疗后血清UA浓度升高与α1-MG、β2-MG、Hs-CRP具有良好的相关性。四项联合检测可为抗结核药物早期肾损害的预防及诊断提供更好的实验室依据。

Objective To explore the association of serum α1-MG, β2-MG, and Hs-CRP with UA level in patients with pulmonary tuberculosis （PTB） after anti-tuberculosis treatment and the clinical value of combined detection in the assessment of early renal damage caused by anti-TB drugs. Methods 3 mL venous blood was collected before and at the end of anti-tuberculosis treatment. The related serological test was performed. Results After treatment, serum concentrations of UA, α1-MG, β2-MG, and Hs-CRP were significantly elevated, as compared with the baselines, with significant statistical differences （P 〈 0.05, P 〈 0.01, P 〈 0.01, and P 〈 0.01, respectively）. The positive rate of single detection was higher and the positiverate of combined detection was as high as 87.5%, with a significant statistical difference （P 〈 0.05）. An increase in serum UA concentration was significantly correlated with α1-MG, β2-MG, and Hs-CRP （r = 0.64, 0.72, and 0.73; P 〈 0.01）. Conclusions An elevation in serum concentration of UA in patients with pulmonary tuberculosis after anti-tuberculosis treatment is associated with α1-MG, β2-MG, and Hs-CRP. The combined detection for four biomakers can provide better test support for the prevention and diagnosis of early renal damage associated with anti-tuberculosis drugs.