探讨尿N-乙酰-β-D-氨基葡萄糖苷酶检测对原发性肾病综合征的临床价值

Discusses the urine N -acetyl- β -D -amino grape glycosidase to test the application value of the primary nephrotic syndrome

目的探讨尿N-乙酰-β—D-氨基葡萄糖苷酶（N—aeetyl—β—D--ucosa minidase，NAG）检测对原发性肾病综合征患者的临床价值。方法选择2008年12月-2011年5月在新疆维吾尔自治区人民医院肾病科住院的原发性肾病综合征患者52例为病例组，对患者使用激素前、后采用对硝基苯酚（PNP）比色法检测尿NAG，并对检测结果进行比较及统计学分析。结果原发性肾病综合征患者使用激素治疗后，检测尿NAG阳性率为9．62％，尿蛋白定性结果为（-）～＋，差异具有统计学意义（P〈0．05）。结论尿NAG酶检测可以作为原发性肾病综合征的敏感指标，对疗效判断及延缓肾脏疾病的进展具有重要的临床意义。

Objectives To investigate the clinical value of urine NAG in Primary nephrotic syndrome patients. Methods 52 patients with primary nephrotic syndrome were enrolled who were in - patients, dated from December 2008 to May 2011, in patients before and after the use of hormone by colorimetric method to detect the urine NAG, and the detection results compare and statistical analysis. Results Primary nephrotic syndrome patients use hormone therapy, the detection of positive urine NAG for 9.62%, urinary protein qualitative results for （ - ） - ＋, a statistically significant difference（ P 〈 0.05 ）. Conclusions Urine NAG enzyme detect can as a primary nephrotic syndrome sensitive indexes, the curative judgment and delay the progress of kidney disease has an important clinical significance.