D-二聚体和肌钙蛋白Ⅰ联合检测在急性心肌梗死早期诊断中的临床价值

The Clinical Value of Determining D-Dimer combined with cTnⅠ in the Early Diagnosis of Acute Myocardial Infarction

目的探讨D-二聚体(DD)和心肌肌钙蛋白Ⅰ(cTnⅠ)联合检测在急性心肌梗死(AMI)早期诊断中的临床价值。方法对47例AMI患者(观察组)及41例非心血管疾病患者(对照组)采血进行DD及cTnⅠ定性测定并比较。结果观察组DD及cTnⅠ检测阳性率分别为78.72%和87.23%,对照组分别为9.75%和0,两组比较差异有统计学意义(P<0.01)。观察组DD、cTnⅠ单独检测时,其敏感度分别为78.72%、87.23%,特异度分别为90.24%、100%;而两项联合检测时,其敏感度增加至93.61%,特异度仍达95.12%。结论联合检测血浆DD与cTnⅠ可明显提高AMI的早期诊断率。

Objective To investigate the clinical value of detecting D-Dimer（DD） combined with cTnⅠ in the early diagnosis of acute myocardial infarction（AMI）.Methods The plasma DD and cTnⅠ were determined and compared in 47 patients with AMI（observation group） and 41 patients excluding cardiovascular diseases（control group）.Results The positive rates of DD and cTnⅠ in observation group were higher than the control（78.72% vs 9.75%,87.23% vs 0,both P〈0.01）.The separate test of DD and cTnⅠ in observation group,sensitivity were 78.72%,87.23% respectively,specificity were 90.24%,100% respectively.While the union test,sensitivity and specificity were 93.61%,95.12%.Conclusion Determining plasma DD combined with cTnⅠ can obviously enhance the early diagnosis rate ofAMI.