某区322株结核杆菌的耐药性分析

Analysis on the Drug resistance of 322 Cases of Mycobacterium Tuberculosis in A District

目的了解惠州市结核病防治院322株痰培养阳性结核杆菌的耐药情况,为临床合理用药提供理论依据。方法以我院322株痰培养阳性的结核杆菌为研究对象,用比例法进行一线结核用药的药敏实验。结果 322株结核分枝杆菌对4种抗结核药物全部耐药者36例,占10.84%;以耐链霉素为最高,占35.8%。结论惠州市结核病耐药情况仍然十分严峻,应加强结核病临床治疗的管理,制定合理化疗方案,防止耐药菌传播。

Objective To understand the status of drug resistance in 322 Cases of Mycobacterium tuberculosis in sputum of patients with culture-positive strains isolated in Huizhou city tuberculosis institute,and to provide evidence for clinical rational chemotherapy.Methods In our hospital,322 Cases of Mycobacterium tuberculosis in sputum with culture-positive strains isolated as the research object,with proportion method for first-line tuberculosis drugs medication to analysis the drug resistance.Results 36 cases of 322 mycobacterium tuberculosis were resistance in four kinds of anti-TB drugs,occupied 10.84%,in which S-resistance was highest,occupied 35.8%.Conclusion The drug resistance of tuberculosis mycobacterium in Huizhou area was serious,so we should strengthen the management of the clinical treatment of tuberculosis,the development of rational chemotherapy to prevent the spread of resistant bacteria.