肥胖哮喘患者血清interleukin-17与瘦素的关系

目的研究肥胖型哮喘患者外周血白细胞介素-17与瘦素的关系。方法肥胖哮喘患者(肥胖哮喘组)、非肥胖哮喘患者(哮喘组)及非肥胖健康者(对照组)各20例,用ELISA法测定血清中瘦素及IL-17的水平,以Pearson分布分析两者之间的关系。结果肥胖哮喘组、哮喘组和对照组的血清IL-17水平分别为(427.01±20.74)、(347.12±22.07)、(215.55±23.00)pg/mL,差异有统计学意义(P<0.05)。肥胖哮喘患者的血清IL-17和瘦素水平成正相关(r=0.417,P<0.05)。结论肥胖哮喘患者体内存在明显的Th17炎症,且与肥胖有一定的相关性。

Objective To investigate the relationship of serum interleukin-17（IL-17） and serum leptin of obese asthma patients. Methods 20 obese asthma patients, 20 non-obese asthma patients and 20 non-obese healthy people were enrolled as obese asthma group, asthma group and control group. Serum IL-17 and lepfin were detected by ELISA. The correlation of serum IL-17 and leptin was analyzed by pearson distribution. Results The level of serum IL- 17 in obese asthma group, asthma group and control group were （427.01±20.74）, （347.12±22.07）, （215.55±23.00） pg/mL respectively. The differences in three groups has statistical significance （P〈0.05）. There is a significant correlation between serum 1L- 17 and leptin in obese asthma group （r=0.417, P〈0.05）. Conclusion Obese asthma patients have a intense Thl7 inflammation which seem to be related to leptin.