卡铂联合紫杉醇化疗治疗老年晚期食管癌23例临床观察

目的观察卡铂联合紫杉醇组成的CT方案治疗老年晚期食管癌的近期疗效及不良反应。方法选2000年6月-2010年6月来汕头大学医学院肿瘤医院就诊的晚期食管癌老年患者46例,随机平均分成两组,实验组应用卡铂(AUC=5)加紫杉醇(175mg/m2)进行治疗,对照组应用常规的治疗方法进行治疗。化疗后评价疗效、不良反应。结果实验组23例患者中完全缓解2例,部分缓解10例,稳定9例,进展2例,总有效率52.2%,中位疾病进展时间3.4个月。对照组23例患者中完全缓解0例,部分缓解5例,稳定11例,进展7例,总有效率21.7%。两组患者中主要不良反应有白细胞、血小板减少,恶心及呕吐,脱发,其中Ⅲ～Ⅳ度白细胞减少21.7%,Ⅲ～Ⅳ度血小板减少17.4%,Ⅲ度恶心、呕吐8.6%,Ⅲ～Ⅳ度脱发78.3%。其中对照组患者的不良反应较实验组的明显。结论卡铂联合紫杉醇方案治疗老年晚期食管癌有较好的疗效,且不良反应可以耐受。

Objective To evaluate the efficacy and adverse reactions of carboplatin （CBP） combined with paclitaxel in the treatment of elderly advanced esophageal cancer. Methods CBP（AUC=5） and paclitaxel were administered every 3 weeks to 23 patients with elderly advanced esophageal cancer. Results The total effective rate was 52.2% with complete remission of 2 cases and partial remission of 10 cases.Grade 3/4 leucopenia was occurred in 21.7% patients,grade 3/4 thrombocytopenia was 17.4%,grade 3 nausea and vomiting was 8.6%, grade 3/4 alopecia was 78.3%. Conclusion CBP combined with paclitaxel is a safe and effective method for elderly advanced esophageal cancer.