格列吡嗪致不良反应52例文献分析

Analysis of Adverse Drug Reactions Caused by Glipizide

目的:了解格列吡嗪致不良反应(ADR)的发生特点及规律,为临床合理用药提供参考。方法:对格列吡嗪所致的52例ADR文献进行统计,分析格列吡嗪致ADR患者的性别、年龄、ADR史、用药情况、临床表现、用药原因及合并疾病等。结果:格列吡嗪致ADR患者的男女性别比例为1:1.2,平均年龄为(63.4±6.6)岁。有48.1%的患者存在不合理用药行为,32.7%的患者联合用药。ADR临床类型以低血糖反应为主(占75.0%),其中94.2%的患者可治愈或好转。结论:格列吡嗪可引起较为严重的ADR,甚至可致死,使用时须慎重考虑患者年龄、用法用量及合并疾病等相关因素,做到合理用药,减少ADR的发生。

OBJECTIVE ： To explore the general regularity and characteristics of adverse drug reaction of glipizide, and to pro- vide reference for the rational use in the clinic. METHODS ： 52 cases induced by glipizide were statistically analyzed in terms of pa- tient＇s age, gender, ADR history, clinical manifestation, use reasean and primary desease and so on. RESULTS： The ratio of ma- le to female was 1 ： 1.2, with average age of （63.4 ± 6.6） years old. 48.1% of the patients use drugs unreasonably, and 32.7 % com- bined use of drugs. Clinical types of ADR mainly were hypoglycemic （75.0%）, and 94.2% of cases cured. CONCLUSIONS ：Glipi- zide can cause severe adverse drug reactions, and even can cause death. We must be carefully considered about the age, usage and dosage and other factors when using. Rational drug use can reduce the incidence of ADR.