玻璃酸钠治疗膝关节骨性关节炎的成本-效果分析

Cost-effectiveness Analysis of Hyaluronate Sodium in the Treatment of Osteoarthrosis of Knee

目的:评价玻璃酸钠治疗膝关节骨性关节炎的临床疗效及成本-效果。方法:将80例膝关节骨性关节炎患者随机均分为观察组和对照组,观察组患者给予玻璃酸钠注射液25mg治疗,对照组给予鹿瓜多肽注射液16mg治疗,观察两组患者的临床疗效,比较其成本-效果比。结果:观察组患者的总有效率为95.00%,显著高于对照组(70.00%),且成本-效果比(C/E)显著低于对照组,差异均有统计学意义(P<0.05)。经敏感度分析,观察组患者的C/E亦低于对照组,差异有统计学意义(P<0.05)。两组患者均未见不良反应发生。结论:玻璃酸钠治疗膝关节骨性关节炎的临床疗效显著,成本-效果更优。

OBJECTIVE： To observe the clinical efficacy and the cost-effectiveness ratio of hyaluronate sodium in the treatment of osteoarthrosis of knee. METHODS： 80 patients of osteoarthrosis of knee were randomly divided into observation group and con- trol group; observation group received hyaluronate sodium 25 mg, while control group was given Cervus and cucumis polypeptide 16 rag; clinical efficacies of 2 groups were observed and the cost-effectiveness ratios were compared. RESULTS： The total effec- tive rate of observation group was 95.00%, while was higher than that of control group （70.00%）; the cost-effectiveness （C/E） ra- tio of observation group was lower than that of control group, and the difference was statistically significant （P〈0.05）. As for sen- sitivity analysis, the C/E of observation group was lower than that of control group, and the difference was statistically significant （P〈0.05）. There was no ADR in both groups. CONCLUSIONS： Hyaluronate sodium is significantly effective in the treatment of osteoarthrosis of knee with low C/E ratio.