64排CT肝灌注成像评价肝癌介入治疗疗效

CTPI: Evaluation on the Effectiveness of transcatheter Arterial Chemoembolization in Treatment of Liver Cancers

目的探讨64排CT肝灌注成像评价肝癌介入治疗后病灶边缘活性的应用价值。方法对25例行肝动脉化疗栓塞术(TACE)治疗的肝癌患者,进行常规三期肝增强扫描及64排CT灌注成像。对获取灌注扫描所得图像自动生成时间-密度曲线(TDC),计算灌注参数。结果 TACE术后肝癌边缘活性灶与非瘤区肝组织的血流量(BF)、血容量(BV)、对比剂平均通过时间(MTT)、肝动脉指数(HAI)具有显著统计学差异(P<0.001)。与肝脏三期增强扫描相比,在病灶边缘活性判断上,64排CT肝灌注成像有较高的敏感性。结论 64排CT灌注成像在肝癌TACE术后病灶边缘活性灶评估中具有很高的应用价值。

Objective To discuss the value of 64 row CTPI（CT Perfusion Imaging） in judgment of the activity of the margin of lesions to evaluate the effectiveness of TACE（Transcatheter Arterial Chemoembotization） in treatment of liver cancers. Methods Conventional phase III enhancement scans and 64 row CTP! were performed in 25 liver cancer patients who had been treated with TACE. Based on the TDC（Time-density Curve） that was automatically generated by CTPI, perfusion parameters like BF（Blood Flow）, BV（Blood Volume）, MTT（Mean Transit Time） and HAl（Hepatic Arerial Index） were calculated. Results The difference in BF, BV, MTT and HAI of liver tissue between the tumor area and the non-tumor area was statistically significant（P〈0.001）. In comparison with the phase III enhancement scan, 64 row CTPI showed higher sensitivity in judgment of the activity of the margin of lesions. Conclusion Application of 64 row CT perfusion imaging in judgment of the activity of the margin of lesions is of great importance to evaluate the effectiveness of TACE in treatment of liver cancers.