共轭聚合物的功能化及在生物/化学分析领域的应用

Functionalized Conjugated Polymers and Their Application in the Biological and/or Chemical Analysis

共轭聚合物具有电子高度离域的共轭结构及优异的光吸收和发射特性,在有机电子、化学/生物传感、医学诊断及生物成像等领域具有广泛的应用。特定基团功能化的共轭聚合物含有可特异性识别生物/化学分子的功能基团(如糖基、生物素、羧基、氨基酸、肽段、核酸、抗体、氨基、巯基等),进一步拓宽了共轭聚合物在生物/化学分析领域的应用。本文从功能化基团的不同类别出发,对近年来共轭聚合物的功能化方法及其在生物/化学分析领域的应用(如蛋白质、病原体、Hg2+、Pb2+检测)进行了综述,并对该领域的发展前景进行了展望。

Conjugated polymers with large, delocalized molecular structure have been widely used in the field of organic electronics, biological and/or chemical sensing, diagnosis and bioimaging due to their unique optical absorption and emission characteristics. Conjugated polymers functionalized by special groups, such as glycosyl, biotin, carboxyl, amino acid, peptide, nucleic acid, antibody, amino, thiol and so on, have ability to recognize certain biomolecules or heavy metal ions. Here, we review the recent development of functionalized conjugated polymer and their application in the biological and/or chemical analysis on the basis of functional groups of different types. Methods for functionalization of conjugated polymers, the application in the detection of proteins, pathogens,Hg2＋ and Pb2＋ , and future development of this area are also included.