脑小血管病的发病机制

Pathogenesis of cerebral small vessel diseases

脑小血管病是指颅内小血管病变引起的缺血性或出血性疾病。虽然人们对其发病机制进行了大量研究，但目前仍不明确。文章从内皮功能障碍、血脑屏障受损、缺血和低灌注、淀粉样物质沉积和遗传因素等方面对脑小血管病的发病机制进行了综述。

Cerebral small vessel diseases refer to small intracranial vascular lesions caused ischemic or hemorrhagic disease. Although researches have performed a large number of studies for its pathogenesis, it remains unclear now. This article reviews the pathogenesis of cerebral small vessel diseases from endothelial dysfunction, blood-brain barrier damage, ischemic and hypoperfusion, amyloid deposition, and genetic factor.