摘要
目的:观察芪蓟肾康颗粒对IgA肾病大鼠肾组织IL-13的表达及血清循环复合物(CIC)浓度的影响,探讨芪蓟肾康颗粒治疗IgA肾病的机制。方法:采用口服牛血清白蛋白(BSA)制备实验性IgA肾病大鼠模型。芪蓟肾康颗粒及替米沙坦于实验第8周开始灌胃给药,每日1次,连续5周,至实验12周末取血检测CIC含量,取肾脏组织检测IL-13表达。结果:与模型组比较:芪蓟肾康颗粒中、高剂量组IL-13表达下降(P<0.01),芪蓟肾康颗粒各剂量组血清CIC浓度均下降(P<0.01)。与替米沙坦组比较:芪蓟肾康颗粒中、高剂量组IL-13表达差异有统计学意义(P<0.01),中药各剂量组血清CIC浓度差异无统计学意义(P>0.05)。结论:芪蓟肾康颗粒有调节IgA肾病大鼠肾组织IL-13表达及血清CIC浓度的作用。
Objective：To observe the effect of Qijishenkang Granule on IgA nephropathy in renal tissue of rats with IL - 13 expression and circulating immune complexes（CIC） from serum concentration effects on Qijishenkang Granule on treatment of IgA nephropathy mechanism. Methods：Preparation of oral bovine serum albumin（BSA） experimental IgA nephropathy rat model. Qijishenkang Granule and telmisartan in the eight weeks of the experiment gavage once daily for five consecutive weeks, 12 weekend blood detection of circulating immune complexes content to experiment, take the kidney tissue detected IL- 13 expressed. Results： Compared with the model group： Qijishenkang Granule middle dose group and high dose group reduced expression of IL -13 （P 〈 0.01 ）, Qijish- enkang Granule in each dosage group CIC from serum concentrations were decreased（P 〈 0.01 ）. With telmisartan group comparison： Qijishenkang Granule middle dose group and high dose group the expression of IL - 13 had significant difference（ P 〈 0.01 ）, the dose of Chinese medicine serum CIC concentrations had no significant difference （ P 〉 0.05 ）. Conclusion： Qijishenkang Granule have the role of regulating of IgA nephropathy IL - 13 expression in renal tissue and serum CIC concentration.
出处
《中国中西医结合肾病杂志》
2013年第5期388-391,共4页
Chinese Journal of Integrated Traditional and Western Nephrology
基金
科技部重大新药创制专题项目(No.2009ZX09103)
