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EMT与肾间质纤维化 被引量：7

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摘要 肾间质纤维化（renal interstitial firosis,RIF）是终末期肾病最特征性的表现,与肾衰竭的进展密切相关。RIF相关的细胞外基质（extracellular matrix,ECM）主要肾间质肌纤维母细胞（myofibroblast,MFB）合成分泌[1]。明确MFB的来源,对研究肾间质纤维发生发展意义重大。传统观点认为,
作者 刘其锋 叶建明
机构地区 江苏省昆山市第一人民医院 江苏大学附属昆山医院肾脏内科
出处 《中国中西医结合肾病杂志》 2013年第5期467-468,共2页 Chinese Journal of Integrated Traditional and Western Nephrology
基金 2012年江苏省昆山市社会发展科技计划资助项目(No.ks1228) 苏州市科技指导性项目(No.SYSD2011024)
关键词 肾间质纤维化 EMT matrix 肌纤维母细胞 终末期肾病 细胞外基质 合成分泌 特征性
分类号 R692 [医药卫生—泌尿科学]
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参考文献22

  • 1Meran S,Steadman R.Fibroblasts and myofibroblasts in renal fibrosis,Int.J Exp Path,2011,92(3):158-167.
  • 2Kriz W,Kaissling B,Le Hir M.Epithelial-mesenchymal transition (EMT) in kidney fibrosis:fact or fantasy? J Clin Invest,2011,121(2):468-474.
  • 3Greenburg G,Hay ED.Epithelia suspended in collagen gels can lose polarity and express characteristics of migrating mesenchymal cells.J Cell Biol,1982,95(1):333-339.
  • 4赵宗江,李相辉.上皮-间质转化信号转导在肾间质纤维化中机制的研究进展[J].中国中西医结合肾病杂志,2007,8(2):113-115. 被引量：10
  • 5Yang J,Liu Y.Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis.Am J Pathol,2001,159(4):1465-1475.
  • 6Peinado H,Quintanilla M,Cano A.Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines:mechanisms for epithelial mesenchymal transitions.J Biol Chem,2003,278(23):21113-21123.
  • 7熊璟,李航,周全荣.中医药对肾小管上皮-间充质转变作用的干预研究概况[J].中国中西医结合肾病杂志,2006,7(12):743-744. 被引量：4
  • 8Liu Y.Epithelial to mesenchymal transition in renal fibrogenesis:Pathologic significance,molecular mechanism,and therapeutic intervention.J Am Soc Nephrol,2004,15(1):1-12.
  • 9Iwano M,Plieth D,Danoff TM,et al.Evidence that fibroblasts derive from epithelium during tissue fibrosis.J Clin Invest,2002,110(3):341-350.
  • 10Simonson MS.Phenotypic transitions and fibrosis in diabetic nephropathy.Kidney Int,2007,71(9):846-854.

二级参考文献48

共引文献11

同被引文献98

  • 1Inagi R. Endoplasmic reticulum stress as a progression factor for kidney injury[J]. Curt Opin Pharmaeol, 2010, 10(2) : 156 - 165.
  • 2Tanjore H, Lawson WE, et al. Endoplasmlc reticulum stress as a pro- fibrotic stimulus [ J ]. Biochim Biophys Acta, 2013, 1832 (7) : 940 -947.
  • 3Ron D, Walter P. Signal integration in the endoplasmic reticulum unfolded protein response [ J ]. Nat Rev Mol Cell Biol, 2007, 8 (7) : 519 -529.
  • 4Ma Y, Brewer JW, Diehl JA, et al. Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response[J]. J Mol Biol, 2002, 318(5) : 1351 - 1365.
  • 5Tabas I, Ron D. Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress[ J ].Nat Cell Biol, 2011, 13 ( 3 ) : 184 - 190.
  • 6Wu J, Rutkowski DT, Dubois M, et al. ATF6alpha optimizes long - term endoplasmic reticulum function to protect cells from chronic stress[ Jl. Dev Cell, 2007, 13(3) : 351 -364.
  • 7Lenna S, Trojanowska 9/1. The role of endoplasmic reticulum stress and the unfolded protein response in fibrosis[ J]. Curr Opin Rheu- matol, 2012, 24(8): 663-668.
  • 8Kimura K, Jin H, Ogawa M, et al. Dysfunction of the ER chaper- one BiP accelerates the renal tubular injury[J]. Biochem Biophys Res Commun,2008, 366(4) :1048 - 1053.
  • 9Wu J, Zhang R, Torreggiani M, et al. Induction of diabetes in aged C57B6 mice resuhs in severe nephropathy: an association with oxidative stress, endoplasmic reticulum stress, and inflamma- tion[J]. Am J Pathol, 2010, 176(5) : 2163 -2176.
  • 10Lindenmeyer MT, Rastaldi MP, Ikehata M, et aL Proteinuria and hyperglycemia induce endoplasmic reticulum stress[ J]. J Am Soc Nephrol, 2008, 19 ( 11 ) : 2225 - 2236.

引证文献7

二级引证文献38

中国中西医结合肾病杂志
2013年 第5期

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