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MTA-1与KISS-1在膀胱癌中的表达及临床病理意义 被引量：3

Expression and clinicopathological significance of MTA-1 and KISS-1 in bladder cancer
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摘要 目的研究肿瘤转移相关基因1(MTA-1)与肿瘤转移抑制基因(KISS-1)表达蛋白在膀胱癌中的表达及临床病理意义。方法采用免疫组化SP法检测65例膀胱癌组织和15例膀胱正常组织中MTA-1和KISS-1的表达,结合临床资料及组织病理学特点探讨MTA-1和KISS-1基因表达与膀胱癌浸润和转移的关系。结果 MTA-1蛋白在膀胱癌组织阳性表达率明显高于膀胱正常组织(53.85%vs.6.67%)(P<0.01);KISS-1蛋白在膀胱癌组织阳性表达率明显低于膀胱正常组织(40.00%vs.86.67%)(P<0.01);其基因表达与病理分级、临床分期、淋巴结转移密切相关(P<0.05)。膀胱癌组织中MTA-1与KISS-1蛋白表达呈负相关(P<0.01)。结论 MTA-1蛋白高表达和KISS-1蛋白低表达与膀胱癌的浸润、转移密切相关,可作为诊断膀胱癌患者转移、复发和判断预后的重要参考指标,有望成为膀胱癌基因治疗的新靶点。 Objective To study the expression and clinicopathological significance of metastasis-associated gene I（MTA-1） and tumormetastasis KISS-1 in bladder cancer. Methods The expressions of MTA-1 and Kiss-1 were detected by immunohistochemical SP technique in 65 cases with bladder cancer （group A） and 15 normal controls （group B）. The association between the expressions of MTA-1 and Kiss-1 and clinicaopathological parameters was analyzed. Results The positive rate of MTA-1 was higher in group A than that in group 13（53.85% vs. 6.67%）（P〈0. 01）. The positive rate of KISS-1 was lower in group A than that in group B（40.00% vs. 86.67%） （P〈0. 01）. The expressions of MTA-1 and Kiss-1 were closely related to the TNM stage, infiltration and metastas of bladder cancer（P〈0. 05）. The expression of MTA-1 was negatively correlated to that of KISS-1 in bladder cancer（P〈0. 01）. Conclusion High expression of MTA-1 and low expression KISS-1 are significantly involved in the infiltration and metastas of bladder cancer. Detection of MTA-1 and KISS-1 in the bladder cancer may be useful markers for predicting the recurrence, metastasis and prognosis in the patients with bladder cancer, which is likely to be a new target of gene therapy of bladder cancer.
作者 杨占锋 许长宝 赵兴华 胡文辉 桂琦
机构地区 郑州大学第二附属医院泌尿外科 郑州大学泌尿外科研究所
出处 《江苏医药》 CAS 北大核心 2013年第11期1295-1298,共4页 Jiangsu Medical Journal
关键词 膀胱癌 肿瘤转移相关基因1 肿瘤转移抑制基因 Bladder cancer Metastasis-associated gene 1 KISS-1
分类号 R737 [医药卫生—肿瘤]
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参考文献13

  • 1Nawa A,Nishimori K,Lin P,et al. Tumor metastasis-associated human MTA1 gene j its deduced protein sequence,localization,and association with breast cancer cellproliferation using antisense phosphorothioate oligonucleo-tide[J]. J Cell Biochem,2000,79(2):202-212.
  • 2姚宏亮,杨竹林,李永国,刘国文.转移抑制基因Kiss-1和KAI-1在胃癌组织中表达的原位杂交研究[J].中华胃肠外科杂志,2007,10(3):274-277. 被引量：11
  • 3Pencil SD,Toh Y,Nicolson GL. Candidate metastasis-associated genes of the rat 13762NF mammary adenocar-cinoma[J]. Breast Cancer Res Treat,1993,25(2):165-174.
  • 4Toh Y,Pencil SD,Nicolson GL. Analysis of the completesequence of the novel metastasis-associated candidate gene,mtal,differentially expressed in mammary adenocarcinomaand breast cancer cell lines[J]. Gene,1995,159(1):97-104.
  • 5Kai L,Wang J,Ivanovic M,et al. Targeting prostate cancerangiogenesis through metastasis-associated protein 1 [J].Prostate,2011,71(3):268-280.
  • 6Toh Y,Ohga T,Endo K,et al. Expression of the metastasis-associated MTA1 protein and its relationship to deacetylationof the histone H4 in esophageal squamous cell carcinomas[J]. Int J Cancer,2004,110(3):362-367.
  • 7杨朋,康健.MTA1和KAI1蛋白在声门上型喉癌组织中的表达及其临床意义[J].江苏医药,2010,36(21):2518-2520. 被引量：5
  • 8Ryu SH,Chung YH,Lee H,et al. Metastatic tumor antigen 1is closely associated with frequent postoperative recurrenceand poor survival in patients with hepatocellular carcinoma[J]. Hepatology,2008,47(3):929-936.
  • 9Nicolson GL,Nawa A,Toh Y,et al. Tumor metastasis-associated human MTA1 gene and its MTA1 proteinproduct:role in epithelial cancer cell invasion,proliferationand nuclear regulation [J]. Clin Exp Metastasis,2003,20(1):19-24.
  • 10Lee JH,Miele ME,Hicks DJ,et al. KISS-1,a novel humanmalignant melanoma metastasis-suppressor gene[J]. J NatlCancer Inst,1996,88(23):1731-1737.

二级参考文献27

  • 1Van Rhijin BW,Van der Poel HG,van der Kwast TH. Urine markers for bladder cancer surveillance:a systematic review [J].Eur Urol, 2005,47 (6) : 736-748.
  • 2Lee JH,Miele ME,Hicks DJ,et al. KISS-I a novel human malignant melanoma metastasis suppressor gene [J]. J Natl Cancer Inst, 1996,88 (23) : 1731-1737.
  • 3West A, Vojta PJ, Welch DR, et al. Chromosome localization and genomic structure of the KISS-1 metastasis suppressor gene (KISS-1) [J]. Genomics, 1998,54 ( 1 ) : 145-148.
  • 4Ohtaki T,Shintani Y,Honda S,et al. Metastasis suppressor gene KISS-1 encodes pep tide ligand of a G-protein coupled receptor[J]. Nature, 2001,411 (6837) : 613-617.
  • 5Mitchell DC,Abdelrahim M,Weng J,et al. Regulation of KISS-1 metastasis suppressor gene expression in breast cancer cells by direct interaction of transcription factors activator protein-alpha and specificity protein-1 [J ]. J Biol Chem, 2006;281 ( 1 ) :51-58.
  • 6Dhar DK,Naora H,Kubota H,et al. Downregulation of KISS-1 expression is responsible for tumor invasion and worse prognosis in gastric carcinoma[J]. Int J Cancer, 2004,111 (6) : 8868-8872.
  • 7Yoshioka K, Ohno Y, Horiguchi Y, et al. Effects of a KISS-1 peptide, a metastasis suppressor gene, on the invasive ability of renal cell carcinoma cells through a modulation of a matrix metalloproteinase 2 expression [J].Life Sci, 2008,83 ( 9-10) : 332-338.
  • 8Sanchez-Carbayo M, Capodieci P, Cordon-Cardo C. Tumor suppressor role of KISS-1 in bladder cancer: loss of KISS-1 expression is associated with bladder cancer progression and clinical outcome [J]. Am J Pathol, 2003,162( 2 ) : 609-617.
  • 9Katagiri F, Nagai K, Kida A,et al. Clinical significance of plasma metastin level in pancreatic cancer patients[ J ]. Oncol Rep, 2009,21 (3):815-819.
  • 10Clark EA, Brugge JS. Integrins and signal transduction pathway: the road taken[J]. Science, 1995,268 (5208) : 233-239.

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江苏医药
2013年 第11期

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