摘要
目的对中老年慢性肾脏病(cKD)患者的动脉硬化程度进行比较,探讨静脉血中炎性蛋白分子与动脉硬化的关系。方法选取慢性肾脏病老年患者87例,中年患者64例。晨起空腹采取静脉血,ELISA法检测血清白细胞介素(IL)、肿瘤坏死因子(TNF-α)、超敏C-反应蛋白(hs-CRP),同时测量患者踝臂脉搏波传导速度(baPwV)。结果两组患者血中炎性蛋白分子IL-18、IL-6、TNF-n和hs-CRP水平均随慢性肾脏病的严重程度增加而增高,且老年组高于中年组;baPWV〉1400cm/s检出率老年组(30例,34.5%)高于中年组(11例,17.2%),差异有统计学意义(X^2-5.58,P〈0.05)老年组并存高脂血症和高血压者PwV〉1400cm/s的比率分别为100.0%和100.0%,高于并存糖尿病(45.5%)和心脏病者(40.0%),差异有统计学意义(P〈0.05);在baPWV〉1400cm/s的患者中,静脉血中炎性蛋白分子IL-18、IL-6、TNF-β和hs-CRP水平均高于baPWV〈1400cm/s的患者,差异有统计学意义(P〈0.05)。结论老年慢性肾脏病患者的动脉硬化程度较中年患者更加严萤,需引起足够莺视。
Objective To compare the degree of atherosclerosis in middle-aged versus elderly patients with chronic kidney disease (CKD), and to explore the relationship between inflammatory molecules in venous blood and atherosclerosis. Methods Totally 87 elderly patients and 64 middle- aged patients with CKD were selected. The vein fasting blood samples were taken in the morning. Serum levels of interleukin (IL)-18, IL-6, tumor necrosis factor (TNF-α), high-sensitivity C-reactive protein (hs-CRP) were measured by enzyme-linked immunosorbent assay (ELISA) and ankle-brachial pulse wave conduction velocity (baPWV) was detected. Results Inflammatory molecules such as IId8, IL-6, TNF-α and hs-CRP levels in venous blood were increased with the severity of CKD in both two groups, and the levels of inflammatory molecules were higher in elderly group than in middle-aged group. There was a signifiant difference in the detection rate of patients with baPWV) 1400 cm/s between elderly group and middle-aged group (30 cases (34.5%) vs. 11 cases (17.2%), )X2 = 5.58, P〈0.05]. The prevalence of PWV〉 1400 cm/s was higher in patients with hyperlipidemia and hypertension than in patients with diabetes or heart disease (elderly group: 100%, 100% vs. 45.5%0, 40%; middle-aged group: 80%, 100% vs. 28.6%, 33.3%, respectively; P(0.05). The inflammatory protein (IL-18, IL-6, TNF-α and hs-CRP) levels were significantly higher in patients with baPWV〉 1400 cm/s than those with baPWV 〈1400 cm/s (P〈0.05). Conclusions The degree of atherosclerosis is more severe in elderly CKD patients than in middle-aged CKD patients, which needs to be taken seriously enough.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2013年第6期598-601,共4页
Chinese Journal of Geriatrics