期刊文献+

乙型肝炎e抗原与免疫耐受研究进展 被引量:1

Current advances in the understanding of HBeAg relation to immune tolerance
原文传递
导出
摘要 乙型病毒性肝炎是世界范围内广泛传播的严重危害人类健康的传染病,全球约有4亿慢性乙型肝炎(cionichepatitisB,CHB)患者。CHB是引起肝硬化和肝细胞癌(hepatocellularcarcinoma,HCC)的主要原因。从HBV感染人体的自然史来看,CHB一般会经历较长的免疫耐受期,此期患者表现为血清乙型肝炎病毒表面抗原(HBsAg)和乙型肝炎e抗原(HBeAg)阳性,HBV复制活跃,
出处 《中华肝脏病杂志》 CAS CSCD 北大核心 2013年第6期477-480,共4页 Chinese Journal of Hepatology
基金 国家自然科学基金(81030007,81171558) 卫生部临床学科重点项目[卫规财函(2010)439号] 教育部“创新团队发展计划”项目(IRT1131)
关键词 肝炎e抗原 乙型 免疫耐受 病毒抗原的特异性T细胞 非特异性免疫 Hepatitis B e antigen Immune tolerance The virusantigens-specific T lymphocyte Innate immunity
  • 相关文献

参考文献37

  • 1Yokosuka O, Takaguchi K, Fujioka S, et al. Long-term use of entecavir in nucleoside-na'/ve Japanese patients with chronic hepatitis B infection. J Hepatol, 2010, 52: 791-799.
  • 2Chang MH. Hepatitis B virus infection. Semin Fetal Neonatal Med, 2007, 12: 160-167.
  • 3Leung N. Treatment of HBeAg-positive chronic hepatitis B with nucleos(t)ide analogues. Liver Int, 2011, 31 Suppl 1: 85-89.
  • 4Chen Y, Li X, Ye B, et al. Effect of telbivudine therapy on the cellular immune response in chronic hepatitis B. Antiviral Res, 2011, 91: 23- 31.
  • 5Milich D, Liang TJ. Exploring the biological basis of hepatitis B e antigen in hepatitis B vires infection. Hepatology, 2003, 38: 1075- 1086.
  • 6Revill P, Yuen L, Walsh R, et al. Bioinformatic analysis of the hepadnavirus e-antigen and its precursor identifies remarkable sequence conservation in all orthohepadnaviruses. J Med Virol, 2010, 82: 104-115.
  • 7Ito K, Kim KH, Lok AS, et al. Characterization of genotype-speeific carboxyl-terminal cleavage sites of hepatitis B virus e antigenprecursor and identification of furin as the candidate enzyme. J Virol, 2009, 83: 3507-3517.
  • 8Lee BO, Jones JE, Peters CJ, et al. Identification of a unique double- negative regulatory T-cell population. Immunology, 2011, 134: 434- 447.
  • 9Akbar SM, Abe M, Masumoto T, et al. Mechanism of action of vaccine therapy in murine hepatitis B vires carriers: vaccine-induced activation of antigen presenting dendritic cells. J Hepatol, 1999, 30: 755-764.
  • 10Chen MT, Billaud JN, Sillberg M, et al. A function of the hepatitis B virus precore protein is to regulate the immune response to the core antigen. Proc Natl Acad Sci USA, 2004, 101: 14913-14918.

同被引文献5

引证文献1

二级引证文献4

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部