门冬氨酸钾镁预防抗艾滋病药物性急性肝损伤效果探讨

Effect of potassium-magnesium aspartate on preventing acute drug-induced liver injury by anti-AIDS drugs

目的:探讨门冬氨酸钾镁预防抗艾滋病药物性急性肝损伤作用。方法:收集艾滋病患者并进行HAART188例,随机分为门冬氨酸钾镁治疗组和对照组各94例,治疗组加服门冬氨酸钾镁2片,3次/d,疗程为3个月。全部患者均定期检查肝肾功能等,观察肝损伤发生率。结果:治疗组肝损伤发生率低于对照组(P<0.01),差异有统计学意义,且未发生不良反应。结论:门冬氨酸钾镁可降低抗艾滋病药物急性肝损伤的发生。

Objective： To evaluate the effect of potassium-magnesium aspartate （PMA） on the pre- vention of acute drug-induced liver injury （DILl） during early antiviral treatment of AIDS. Methods： 188 cases of AIDS received highly active anti-retroviral therapy （HAART） were randomly divided into the PMA treatment group and the control groups with equal patients in each group. Patients in the treatment group were requested to perform PMA 2 tablet, tid for 3 months based on the treatment in the control group. All patients received regular liver injury and kidney examinations, and the occurrence rate of liver injury was observed. Results： The incidence rate of DILI in the treatment group was lower than that of the control group （P〈0.01）, which was of statistical difference. Besides, there was no adverse reaction. Conclusion： PMA can significantly reduce the incidence rate of acute liver injury caused by HIV antiviral drugs.