N-(D,L-异丙酸基)-马来酰亚胺的合成

Synthesis of N- (D,L- alaninyl) maleimide (AMI)

研究了N-(D,L-异丙酸基)-马来酰胺酸(AMA)闭环合成N-(D,L-异丙酸基)-马来酰亚胺(AMI),考察了溶剂、催化剂用量、反应时间对产率的影响,同时也考察了混合溶剂对粗产物重结晶的影响,确定了最佳反应条件。所得N-(D,L-异丙酸基-)马来酰亚胺的产率达52％。本实验具有产率高、溶剂容易回收、AMA不需纯化等优点。

N- (D,L-alaninyl) - maleimide was synthesized through ring closing of N?(D,L- alaninyl) ?maleinamic acid. The effects of solvent, catalytic amount and reaction time on the yield were investigated and the effect of recrystallizing solvent was researched as well. The most optimum conditions was acquired. The yield of AMI can be up to 52% . This technolo-gy has some advantages: solvent was recovered easily, AMA may not be purified and high yield.