脐带间充质干细胞应用的最新进展

The Latest Progress of the Application of Mesenchymal Stem Cells in the Umbilical Cord

脐带间充质干细胞(umbilical cord mesenchymal stem cells,UC-MSCs)主要来自中胚层,是从出生后废弃的胚外组织中分离获得,具有比一般的成体干细胞更强的多能分化能力,而且可以跨胚层分化,可以诱导分化为骨细胞、软骨细胞、内皮细胞、心肌细胞,以及神经细胞、肝脏细胞和胰岛细胞等。这表明脐带来源的干细胞具有多向分化潜能,具有作为细胞替代治疗的种子细胞可能。这篇综述将浅谈UC-MSCs的优势,免疫学特性,并重点探讨其应用的最新进展。

The umbilical cord mesenchymal stem cells,which mainly come from mesoderm,isolated from discarded extra-embryonic tissue after birth,possess stronger pluripotent differentiation ability than the average adult stem cells,in certain condition.They can be induced to differentiate into bone cells,cartilage cells,endothelial cells,cardiac muscle cells,nerve cells,liver cells and islet cells,etc.Indicating that the umbilical cord-derived stem cells have the potential of multiple differentiation,possibly considered as seed cells for cell replacement therapy.In this review,we will discuss the advantages of UC-MSCs,their immunological characteristics,and mainly focus on the latest progress of their application.