ECMO在脓毒症中应用的研究进展

Extracorporeal Membrane Oxygenation in Sepsis

体外膜肺氧合(extracorporeal membrane oxygenation,ECMO)是一种心肺支持技术,临床上能够为严重、可逆性的心肺衰竭患者提供循环、呼吸支持。近年来,新生儿、儿童和成人脓毒症患者应用ECMO治疗的成功报道日渐增多,掀起了脓毒症患者应用ECMO治疗的热潮。然而,ECMO在脓毒症患者中的临床应用却一直存在争议。大量回顾性研究表明新生儿及儿童脓毒症患者中应用的成功率相对较高,成人脓毒症患者应用ECMO治疗例数较少,但仍可在其他治疗无效的前提下尽早尝试ECMO治疗。

Extracorporeal membrane oxygenation（ECMO） is a modified form of cardiopulmonary bypass that allows short-term support for potentially reversible severe acute respiratory and/or cardiac failure in critically ill patients.In recent years,it was reported that more and more neonatal,pediatric and adult patients with sepsis were treated with ECMO successfully,which set off a craze of the application of ECMO in patients with sepsis.However,the clinical application of ECMO in patients with sepsis remains controversial.A large number of retrospective studies have shown that the success rate of application in neonatal and pediatric patients with sepsis is relatively higher.The number of adult patients with sepsis treated by ECMO is small,but ECMO should be tried in these patients who had failed in other treatments as soon as possible.