江苏省HIV阳性的MSM人群梅毒和HSV-2感染及影响因素分析

Prevalence and predictors of syphilis and herpes simplex type 2 virus(HSV-2) infections among HIV-infected men who have sex with men in Jiangsu province

目的:了解江苏省男男性行为人群(men who have sex with men,MSM)中人类免疫缺陷病毒(human immunoddficiency virus,HIV)感染者的梅毒及单纯疱疹病毒Ⅱ型(herpes simplex virus 2,HSV-2)的感染情况及影响因素。方法:2012年3～6月在南京、镇江市整群抽取HIV阳性的MSM 264例,对其进行随访问卷调查,并回顾其病例报告时的问卷信息。静脉血采集进行梅毒和HSV-2检测。结果:264例MSM中梅毒感染率为29.55%(78/264),其中现症梅毒感染率为13.64%(36/264),HSV-2型特异性IgG抗体阳性率为28.03%(74/264)。多因素Logistic回归分析结果显示与现症梅毒感染有统计学意义的因素为感染前6个月内同性性伴数>3人、HSV-2阳性;与HSV-2感染有统计学意义的因素为年龄>35岁、本县区户籍、现症梅毒感染和接受安全套发放服务。结论:应探索新的干预模式和检测策略,以应对梅毒和HSV-2在MSM人群中的传播和流行。

Objective：To analyze the prevalence and predictors of syphilis and herpes simplex type 2 virus （HSV-2） infections among HIV-infected men who have sex with men （MSM） in Jiangsu province, Methods：MSM were convened with Cluster sampling and investigated with follow-up questionnaire survey. We reviewed the case reports of their questionnaire information in Nanjing and Zhenjiang city from March to June,2012. Blood samples were collected to detect syphilis and HSV-2 infections. Results：Total of 264 HIV-infected MSM enrolled in the interview and blood sampling. The prevalence of syphilis and HSV-2 infections was 13.64% （36/ 264） and 28.03% （74/264）,respectively. Multivariate logistic regression analysis showed that active syphilis infection was associated with having more than 3 sex partners in the latest 6 months and HSV-2 infection. The HSV-2 infection was associated with age 〉 35 years old,locality census register,recent syphilis infection and accepting condom issue service. Conclusion：The HIV-infected MSM in Jiangsu province had high infection rates of syphilis and HSV-2. It is necessary to further strengthen and implement and explore new intervention and testing methods.