高血压前期合并糖耐量减低患者妊娠相关血浆蛋白A与白介素6水平变化及其临床意义的观察

Levels of pregnancy associated plasma protein A and interleukin 6 and their clinical significance in prehypertension patients with impaired glucose tolerance

目的观察妊娠相关血浆蛋白A(PAPP-A)和白介素6(IL-6)在高血压前期(PH)合并IGT患者中的水平变化,并探讨其之间的关系。方法入选PH患者100例,其中合并IGT(PH+IGT)者50例,糖耐量正常(PH+NGT)者50例。采用ELISA法测血浆中PAPP-A、IL-6含量。结果 PH+IGT组PAPP-A和IL-6水平高于PH+NGT组[PAPP-A(12.43±3.65)vs(9.50±3.39)mU/L,IL-6(101.64±19.13)vs(87.56±17.32)ng/L,P<0.05]。多因素Logistic回归分析显示,PAPP-A和IL-6是IGT合并PH的部分危险因素。结论 PH合并IGT患者PAPP-A和IL-6水平增高。

Objective To study the levels of pregnancy associated plasma protein A （PAPP-A） and interleukin 6 （IL-6） in patients with prehypertension （PH） and IGT. Methods We recruited 100 prehypertension（PH） patients, among them 50 with normal glucose tolerance （NGT） and 50 with IGT. The levels of pregnancy associated plasma protein A and interleukin 6 were determined by ELISA. Results The levels of PAPP-A and IL-6 in patients with PH and IGT were higher than patients with PH and NGT [-PAPP-A （12. 43±3.65） vs （9.50±3. 39） mU/L, IL-6（101.64±19. 13） vs （87.56±17. 32） ng/L, all P〈0. 053. Multivariate logistic regression analysis showed PAPP-A, IL-6, BMI and systolic blood pressure were predisposing risk factors for perhypertensive patients with IGT. Conclusion PAPP-A and IL-6 are enhanced in prehypertension with IGT.