女性2型糖尿病患者合并高血压对新发心脑血管事件影响的观察

Effect of the complicated hypertension in type 2 diabetes mellitus patients on new-onset cardio-cerebro-vascular events in women population

目的探讨女性T2DM患者合并高血压对新发心脑血管事件的影响。方法采用前瞻性队列研究,选取参加体检的101510名开滦集团职工中1477例女性T2DM患者,随访(48.05±3.09)个月。结果高血压组年龄、BMI、SBP、DBP、脉压、TG、SUA、高敏C反应蛋白(hsC-RP)水平均高于血压正常组(P<0.05)。高血压组总心脑血管事件、脑梗死、心肌梗死和脑出血事件累积发生率高于血压正常组,其中总心脑血管事件、脑梗死事件发生率两组间比较差异有统计学意义(P<0.05)。高血压组发生总心脑血管事件、脑梗死事件的风险分别是血压正常组的2.66、2.96倍。结论女性T2DM患者合并高血压可增加其新发心脑血管事件的风险。

Objective To evaluate the effect of the complicated hypertension in diabetic patients on the new-onset eardio-eerebro-vascular events （CCVE） in women. Methods In this prospective cohort study, the 1477 women T2DM patients were selected from a total of 101510 employees of Kailuan Group for analysis. The follow-up lasted for （48.05±3. 09） months. Results In the hypertension-complicated diabetes group, the averaged age, BMI, SBP, DBP, pulse pressure, TG, SUA, and high sensitivity C-reaction protein （hsC-RP） were all higher than in diabetes group with normal blood pressure （P〈0. 05）. In the hypertension-complicated diabetes group, the incidence of total CCVE, cerebral infarction, myocardial infarction, and cerebral hemorrhage events was 4. 6%, 2.6%, 1.0%, and 1.0% respectively, higher than in diabetes group with normal blood pressure, of them, there was a statistical difference in the incidence of total CCVE and cerebral infarction events （P〈0. 05）. Cox proportional hazard model showed the higher risk for the total CCVE（RR： 2.66）, and for cerebral infarction events （RR： 2. 96） for the female diabetic patients complicated with hypertension. Conclusion The risk of the new-onset cardio-cerebro-vascular events is higher in the female T2DM patients complicated with hypertension.