幽门螺杆菌感染对儿童血小板的影响研究

Study on effect of Helicobacter pyloriinfection on platelet in children

目的探讨幽门螺杆菌(Hp)感染与免疫性血小板减少症(ITP)之间的相关性,为ITP的防治提供更多的理论依据。方法收集医院儿科2010年1月-2012年6月诊治的ITP患儿100例,ITP患儿分为Hp阳性组31例和Hp阴性组69例,另取保健儿童门诊的健康儿童100名作为对照。结果 ITP组和对照组中Hp的感染率分别为31.0%和11.0%,两组之间差异有统计学意义(P<0.05);Hp阴性与阳性组中血小板计数分别为(15.32±4.61)×109/L和(11.07±3.52)×109/L,Hp阴性组的血小板计数显著高于Hp阳性组(P<0.05);Hp阴性与阳性ITP患儿临床治疗的有效率分别为84.1%和61.3%,两组之间差异有统计学意义(P<0.05)。结论 ITP患儿存在较高的Hp感染率,根除Hp有望成为提高ITP患儿临床治疗效果的新措施。

OBJECTIVE To investigate the relationship between Helicobacter pylori （Hp） infection and idiopathic thrombocytopenic purpura （ITP） in children so as to provide theoretical basis for the prevention and treatment of ITP. METHODS A total of 100 children with ITP were enrolled in this study. The patients were divided into two groups： the Hp （＋） group （n=31） and the Hp （--） group （n=69）. Another 100 healthy children were set as controls. RESULTS The incidence rate of Hp infection was 31.0% in the ITP group, 11.0% in the control group, the difference between the two groups was statistically significant （P〈0.05）. The platelet count in the Hp （-） group was （15.32± 4.61） × 10^9/L, significantly higher than （11.07± 3.52） ×10^9/L of the Hp （ ＋ ） group; the effective rate of clinical treatment was 84.1% in the Hp （--） group, 61.3% in the Hp （＋） group, the difference was statistically significant （P〈0.05）. CONCLUSION The incidence rate of Hp infections is high in the ITP chil- dren, and the eradication of Hp maybe a new measure to improve clinical outcomes of treatment of ITP in children.