小儿支气管哮喘急性发作与肺炎支原体感染的相关性研究

Study on correlation between Mycoplasma pneumoniaeinfection and acute exacerbation of bronchial asthma in children

目的探讨小儿支气管哮喘急性发作与肺炎支原体(MP)感染之间的相关性,为小儿支气管哮喘急性发作的诊治提供参考依据。方法对324例小儿支气管哮喘急性发作期患儿(哮喘组)与100例呼吸道感染患儿(对照组)在入院后7d进行血清肺炎支原体抗体(MP-IgM)、咽拭子肺炎支原体-DNA、外周血嗜酸性粒细胞及血清免疫球蛋白E(IgE)检测。结果肺炎支原体检测结果比较,哮喘组阳性率为37.65%,对照组阳性率为24.00%,两组比较差异有统计学意义(P<0.05);哮喘组>6岁患儿肺炎支原体阳性率最高为46.67%,3～6岁患儿阳性率为27.12%,<3岁患儿阳性率为23.08%,不同年龄段肺炎支原体阳性率比较差异有统计学意义(P<0.05);哮喘组肺炎支原体阳性患儿血嗜酸性粒细胞计数为(486.29±242.18)×109,免疫球蛋白E为(650.96±257.84)U/ml,阴性患儿分别(368.52±129.76)×109、(417.42±274.46)U/ml,比较差异有统计学意义(P<0.05)。结论小儿支气管哮喘发作与肺炎支原体感染关系密切,在哮喘发作时常伴有肺炎支原体感染,对小儿支气管哮喘急性发作期患儿进行肺炎支原体检测有助于为临床治疗提供科学依据。

OBJECTIVE To investigate correlation between the Mycoplasma pneumoniae infection and the acute exacerbation of bronchial asthma in children so as to provide basis for the diagnosis and treatment of the acute exacerbation of bronchial asthma in children. METHODS Totally 324 cases of bronchial asthma children with acute attack （the asthma group） and 100 chnildren with respiratory tract infections （the control group） were enrolled in this study. The antibody of M. pneumonia （MP-IgM）, specific DNA of M. pneumoniae（MP-DNA）, peripheral eosinophilia, and serum immunoglobulin E （IgE） were detected 7 days after the admission. RESULTS The positive rate of MP was 37. 65% in the asthma group, 24. 0% in the control group, the difference between the two groups was statistically significant （P〈0.05）. In the asthma group, the positive rate of MP in the children aged more than 6 years old was 46. 67%, the children aged between 3 years and 6 years old 27.12%, the children aged less than 3 years old 23.08%, the difference in the positive rate of MP between the various age groups was statis- tically significant （P〈0.05）. The blood eosinophil counts were （486.29±242.18）×10^9 in the MP positive chil- dren of the asthma group, （368.52±129.76） × 10^9 in the MP negative children＇s the IgE level was （650.96± 257.84） in the MP positive children of the asthma group, （417.42±274.46） U/ml in the MP negative children, the difference was statistically significant（P〈0.05）. CONCLUSION The acute exacerbation of bronchial asthma in children is closely related to the M. pneumoniae infections, and the attach of asthma is usually complicated with M. pneumoniae infections. The detection of MP-IgM maybe helPful to provide a scientific basis for the clinical treatment of acute exacerbation of bronchial asthma in the children.